G Patanè, M Anello, S Piro, R Vigneri, F … - Diabetes, 2002 - Am Diabetes Assoc In rat pancreatic islets chronically exposed to high glucose or high free fatty
acid (FFA) levels, glucose-induced insulin release and mitochondrial glucose
oxidation are impaired. These abnormalities are associated with high basal ... Cited by 102 - Related articles - BL Direct - All 6 versions
N Lameloise, P Muzzin, M Prentki, F … - Diabetes, 2001 - Am Diabetes Assoc The mechanism by which long-term exposure of the β-cell to elevated
concentrations of fatty acid alters glucose-induced insulin secretion has been
examined. Exposure of INS-1 β-cells to 0.4 mmol/l oleate for 72 h ... Cited by 172 - Related articles - BL Direct - All 5 versions
AV Medvedev, J Robidoux, X Bai, W Cao, LM … - Journal of Biological Chemistry, 2002 - ASBMB Current evidence suggests that uncoupling protein-2 (UCP2) is a regulator of
insulin secretion. It is also known that chronic exposure of pancreatic islets
to free fatty acids (FFAs) blunts glucose-stimulated insulin secretion and ... Cited by 75 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org CB Chan, D De Leo, JW Joseph, TS McQuaid, … - Diabetes, 2001 - Am Diabetes Assoc In pancreatic β-cells, glucose metabolism signals insulin secretion by altering
the cellular array of messenger molecules. ATP is particularly important, given
its role in regulating cation channel activity, exocytosis, and events ... Cited by 206 - Related articles - BL Direct - All 5 versions
- ►jlr.org K Tordjman, KN Standley, C Bernal-Mizrachi … - The Journal of Lipid Research, 2002 - ASBMB Fatty acids may promote type 2 diabetes by altering insulin secretion from
pancreatic ß cells, a process known as lipotoxicity. The underlying mechanisms
are poorly understood. To test the hypothesis that peroxisome proliferator- ... Cited by 67 - Related articles - BL Direct - All 5 versions
V Koshkin, X Wang, PE Scherer, CB Chan, … - Journal of Biological Chemistry, 2003 - ASBMB Excessive free fatty acid (FFA) exposure represents a potentially important
diabetogenic condition that can impair insulin secretion from pancreatic -cells.
Because mitochondrial oxidative phosphorylation is a main link between ... Cited by 64 - Related articles - BL Direct - All 5 versions
JW Joseph, V Koshkin, CY Zhang, J Wang, … - Diabetes, 2002 - Am Diabetes Assoc Uncoupling protein 2 (UCP2) may act as an important regulator of insulin
secretion. In this study, β-cell function in UCP2-deficient mice was examined
after a 45% high-fat diet (HFD) to assess its role during the development ... Cited by 119 - Related articles - BL Direct - All 5 versions
E Ito, S Ozawa, K Takahashi, T Tanaka, H … - Biochemical and Biophysical Research …, 2004 - Elsevier Peroxisome proliferator-activated receptor-γ (PPAR-γ) regulates several
cellular functions, but its physiological role in pancreatic islet cells remains
to be investigated. In this study, we confirmed the presence of PPAR-γ in ... Cited by 26 - Related articles - All 4 versions
CB Chan, PE MacDonald, MC Saleh, DC Johns … - Diabetes, 1999 - Am Diabetes Assoc Uncoupling protein 2 (UCP-2) mRNA expression has been shown to be altered by
metabolic conditions such as obesity in humans, but its functional significance
is unknown. The expression of UCP-2 mRNA and protein in normal rat islets ... Cited by 164 - Related articles - BL Direct - All 6 versions
- ►endojournals.org LX Li, F Skorpen, K Egeberg, IH Jorgensen, V … - Endocrinology, 2002 - Endocrine Soc A plausible theory on the functional importance of UCP-2 holds that regulation
of this protein provides a way to dissipate energy in situations of oversupply
to a specific tissue or cell (1, 2). Restraining the build-up of excessive ... Cited by 40 - Related articles - BL Direct - All 4 versions
