AMK Hansen, IT Christensen, JB Hansen, RD … - Diabetes, 2002 - Am Diabetes Assoc Repaglinide and nateglinide represent a new class of insulin secretagogues,
structurally unrelated to sulphonylureas, that were developed for the treatment
of type 2 diabetes. The inhibitory effect of these drugs was investigated ... Cited by 48 - Related articles - BL Direct - All 7 versions
- ►aspetjournals.org M Chachin, M Yamada, A Fujita, T Matsuoka, K … - Journal of Pharmacology and Experimental …, 2003 - ASPET A novel antidiabetic agent, nateglinide, is a D-phenylalanine derivative lacking
either a sulfonylurea or benzamido moiety. We examined with the patch-clamp
method the effect of nateglinide on recombinant ATP-sensitive K + (K ATP ) ... Cited by 20 - Related articles - BL Direct - All 3 versions
M Dabrowski, P Wahl, WE Holmes, FM … - Diabetologia, 2001 - Springer Page 1. The ATP-sensitive potassium (K ATP ) channels are a family of potassium
channels that are inhibited by ATP and activated by MgADP. They thereby couple ... Cited by 64 - Related articles - BL Direct - All 3 versions
Y Sunaga, T Gonoi, T Shibasaki, K Ichikawa, … - European journal of pharmacology, 2001 - Elsevier Mitiglinide (KAD-1229), a new anti-diabetic drug, is thought to stimulate
insulin secretion by closing the ATP-sensitive K + (K ATP ) channels in
pancreatic β-cells. However, its selectivity for the various K ATP ... Cited by 43 - Related articles - All 5 versions
- ►aspetjournals.org A Hambrock, C Loffler-Walz, U Russ, U Lange … - Molecular Pharmacology, 2001 - ASPET ATP-dependent K + channels are composed of pore-forming subunits of the Kir6.x
family and of sulfonylurea receptors (SURs). SUR1, expressed in pancreatic
-cells, has a higher affinity for sulfonylureas, such as glibenclamide, ... Cited by 43 - Related articles - BL Direct - All 2 versions
K Bokvist, M Høy, K Buschard, JJ Holst, MK … - European journal of pharmacology, 1999 - Elsevier The effects of the two prandial glucose regulators, repaglinide and nateglinide,
on ATP-sensitive K + (K ATP ) channel activity, membrane potential and
exocytosis in single rat pancreatic A-cells were investigated using the ... Cited by 17 - Related articles - All 8 versions
F Reimann, P Proks, FM Ashcroft - British Journal of Pharmacology, 2001 - pubmedcentral.nih.gov We have investigated the mechanism of action of the novel anti-diabetic agent
mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of
ATP-sensitive potassium (K ATP ) channel. These possess a common ... Cited by 37 - Related articles - BL Direct - All 3 versions
- ►aspetjournals.org C Loffler-Walz, A Hambrock, U Quast - Molecular pharmacology, 2002 - ASPET Sulfonylurea receptors (SURs) are subunits of ATP-sensitive K + channels (K ATP
channels); they mediate the channel-closing effect of sulfonylureas such as
glibenclamide and the channel-activating effect of K ATP channel openers ... Cited by 19 - Related articles - BL Direct - All 3 versions
MV Mikhailov, EA Mikhailova, SJH Ashcroft - FEBS letters, 2001 - Elsevier We have investigated the structure of the glibenclamide binding site of
pancreatic β-cell ATP-sensitive potassium (K ATP ) channels. K ATP channels are
a complex of four pore-forming Kir6.2 subunits and four sulfonylurea ... Cited by 55 - Related articles - All 5 versions
S Hu - European journal of pharmacology, 2002 - Elsevier Nateglinide is a novel insulinotropic agent for the treatment of type 2
diabetes. It is a -phenylalanine derivative, chemically distinct from
repaglinide and sulphonylureas (glyburide or glimepiride). Although each ... Cited by 22 - Related articles - All 6 versions
