O Tschritter, M Stumvoll, F Machicao, M … - Diabetes, 2002 - Am Diabetes Assoc Genetic factors play an important role in the pathogenesis of type 2 diabetes.
The relevance to type 2 diabetes of the common polymorphism Glu23Lys in the
potassium inward rectifier 6.2 (KIR6.2) gene is still controversial. The ... Cited by 44 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org LM t Hart, TW van Haeften, JM Dekker, M Bot … - Diabetes, 2002 - Am Diabetes Assoc An association between type 2 diabetes and genetic variation in the KIR6.2 gene
has been reported in several populations. Based on in vitro studies with cell
lines expressing the Glu 23 Lys (E23K) mutation, it was recently suggested ... Cited by 19 - Related articles - BL Direct - All 6 versions
C Schwanstecher, B Neugebauer, M Schulz, … - Diabetes, 2002 - Am Diabetes Assoc E23K, a common polymorphism in the pore-forming subunit K IR 6.2 of pancreatic
β-cell ATP-sensitive K + (K ATP ) channels, is functionally relevant and thus
might play a major role in the pathophysiology of common type 2 diabetes. ... Cited by 32 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org C Schwanstecher, U Meyer, M … - Diabetes, 2002 - Am Diabetes Assoc E23K, a common single nucleotide polymorphism in K IR 6.2, the pore-forming
subunit of pancreatic β-cell ATP-sensitive K + channels, significantly enhanced
open probability of these channels, thus reducing their sensitivity toward ... Cited by 124 - Related articles - BL Direct - All 18 versions
EMD Nielsen, L Hansen, B Carstensen, SM … - Diabetes, 2003 - Am Diabetes Assoc The E23K polymorphism of the pancreatic β-cell ATP-sensitive K + (K ATP )
channel subunit Kir6.2 (KCNJ11) is associated with type 2 diabetes in whites,
and a recent in vitro study of the E23K variant suggests that the ... Cited by 146 - Related articles - BL Direct - All 5 versions
- ►hivinfosource.org [PDF] MJ Riedel, P Boora, D Steckley, G de Vries, … - Diabetes, 2003 - Am Diabetes Assoc The commonly occurring E23K and I337V Kir6.2 polymorphisms in the ATP-sensitive
potassium (K ATP ) channel are more frequent in Caucasian type 2 diabetic
populations. However, the underlying cellular mechanisms contributing to ... Cited by 51 - Related articles - BL Direct - All 25 versions
H Inoue, J Ferrer, M Warren-Perry, Y Zhang, … - Diabetes, 1997 - Am Diabetes Assoc Signals derived from the metabolism of glucose in pancreatic beta-cells lead to
insulin secretion via the closure of ATP-sensitive K+ channels (KATP). The
cloning of the gene encoding the beta-cell inward rectifier Kir6.2 (Bir), a ... Cited by 60 - Related articles - All 4 versions
[CITATION] Sequence variants in the pancreatic islet b-cell inwardly rectifying K+ channel Kir6. 2 (Bir) …
H Inoue, J Ferrer, M Warren-Perry, Y Zhang, … - Diabetes-American Diabetes Association, 1997 - [New York, American Diabetes Association] Cited by 28 - Related articles - BL Direct
H Sakura, N Wat, V Horton, H Millns, RC … - Diabetologia, 1996 - Springer Summary The ATP-sensitive K-channel plays a cen- tral role in insulin release
from pancreatic beta cells. This channel consists of two subunits: a sulphonyl-
urea receptor, SUR1, and an inwardly rectifying K- channel subunit, Kir6.2. ... Cited by 71 - Related articles - BL Direct - All 3 versions
L Love-Gregory, J Wasson, J Lin, G Skolnick, … - Diabetologia, 2003 - Springer 2. Wren A, Seal L, Cohen M et al. (2001) Ghrelin enhances appetite and increases
food intake in humans. J Clin Endo- crinol Metab 86: 5992–5995 3. Tschop M,
Weyer C, Tataranni P, Devanarayan V, Ravussin E, Heiman M (2001) ... Cited by 70 - Related articles - BL Direct - All 3 versions
