S Del Prato, P Marchetti, RC Bonadonna - Diabetes, 2002 - Am Diabetes Assoc Type 2 diabetes is a heterogeneous disorder due to prevalent insulin resistance
associated with deficient insulin secretion or to a prevalent defect of insulin
secretion associated with impaired insulin action. The definition is ... Cited by 126 - Related articles - BL Direct - All 5 versions
WI Sivitz - Postgraduate Medicine, 2001 - 万方数据资源系统 Excess fat, excess glucose, or both act on diverse cells and tissues to
counteract insulin-mediated glucose uptake, hepatic regulation of glucose
output, and insulin secretion. These effects are labeled lipotoxicity and ... Cited by 129 - Related articles - BL Direct - All 7 versions
F Purrello, AM Rabuazzo - Diabetes, nutrition & metabolism, 2000 - ncbi.nlm.nih.gov Several data suggest that, during the natural history of Type 2 diabetes (T2DM),
whereas the degree of insulin resistance is quite stable in a single individual,
insulin secretion is often progressively decreasing. The decline in ... Cited by 144 - Related articles - BL Direct - All 3 versions
- ►sherbornegibbs.com [PDF] S Del Prato, R Miccoli, G Penno - The British Journal of Diabetes & Vascular Disease, 2005 - dvd.sagepub.com Abstract L ow insulin sensitivity and a selective loss of acute insulin release
identify those individuals at the highest risk of developing type 2 diabetes.
Normally, the rapid release of insulin after the ingestion of a meal is ... Cited by 1 - Related articles - All 4 versions
S Del Prato - Diabetologia, 2003 - Springer Aims/Hypothesis. A loss of early-phase insulin re- sponse is common in Type 2
diabetic patients and in people with impaired glucose metabolism. It is hy-
pothesized that this alteration is not simply a marker for the risk of ... Cited by 62 - Related articles - BL Direct - All 4 versions
A Cretti, M Lehtovirta, E Bonora, B Brunato … - European Journal of Clinical Investigation, 2001 - interscience.wiley.com DesignFifty-six subjects were studied. A minimal analogic model of β-cell
secretion during the OGTT was applied to all OGTTs (see below). The amount of
insulin secreted over 120' in response to oral glucose (OGTT-ISR; Insulin ... Cited by 43 - Related articles - BL Direct - All 4 versions
L Luzi, RA DeFronzo - American Journal of Physiology- Endocrinology And …, 1989 - Am Physiological Soc LUZI, LIVIO, AND RALPH A. DEFRONZO. Effect of loss offirst- phase insulin
secretion on hepatic glucose production and tissue glucose disposal in humans.
Am. J. Physiol. 257 (Endocrinol. Metab. 20): E241-E246,1989.-To examine the ... Cited by 112 - Related articles - All 3 versions
P Marchetti - Horm Metab Res, 2004 - januvia.se Type 2 diabetes is a heterogeneous disorder caused by concomi- tant impairment
of insulin action (insulin resistance) and insulin secretion [1]. Although
insulin resistance is found in almost all type 2 diabetic patients [2], it ... Related articles - View as HTML - All 2 versions
S Del Prato, A Tiengo, CM del Metabolismo - Diabetes Metab Rev, 2001 - interscience.wiley.com Type 2 diabetes is a heterogeneous disorder characterized by defects in insulin
secretion and action. Insulin resistance is a key feature of type 2 diabetes.
However, insulin resistance alone does not appear to be sufficient to cause ... Cited by 82 - Related articles - BL Direct - All 4 versions
