- ►diabetesjournals.org JE Gerich - Diabetes, 2002 - Am Diabetes Assoc Insulin is released from the pancreas in a biphasic manner in response to a
square-wave increase in arterial glucose concentration. The first phase consists
of a brief spike lasting 10 min followed by the second phase, which reaches ... Cited by 65 - Related articles - BL Direct - All 5 versions
- ►physiology.org SG Straub, GWG Sharp - American Journal of Physiology- Cell Physiology, 2004 - Am Physiological Soc The biphasic secretory response of pancreatic -cells to abrupt and sustained
exposure to glucose is well documented. Some of the ATP-sensitive K + (K ATP )
channel-dependent mechanisms underlying the first phase of insulin release ... Cited by 22 - Related articles - All 3 versions
L Getty, M Hamilton-Wessler, M Ader, MK … - Diabetes, 1998 - Am Diabetes Assoc We examined the hindlimb lymph insulin profile during simulated intravenous
glucose tolerance tests (IVGTTs) in anesthetized dogs to test the following
hypotheses: 1) the biphasic insulin response to intravenous glucose can be ... Cited by 32 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org R Nesher, E Cerasi - Diabetes, 2002 - Am Diabetes Assoc The cellular and molecular mechanisms of insulin secretion are being intensively
investigated, yet most researchers are seemingly unaware of the complexity of
the dynamic regulation of the secretion. In this article, we summarize ... Cited by 55 - Related articles - BL Direct - All 5 versions
JE Gerich - Diabetes, obesity & metabolism, 1999 - ncbi.nlm.nih.gov The data presented from these recent studies raise serious doubt concerning the
commonly held view that insulin resistance is the principal cause of type 2
diabetes: first of all they provide evidence that insulin resistance may ... Cited by 32 - Related articles - All 4 versions
- ►endojournals.org JE Gerich - Journal of Clinical Endocrinology & Metabolism, 2000 - Endocrine Soc Insulin resistance and impaired insulin secretion are usually present in
patients with classic type 2 diabetes as well as in most people with impaired
glucose tolerance (1, 2). Both play important roles not only in determining ... Cited by 47 - Related articles - BL Direct - All 4 versions
AD Cherrington, D Sindelar, D Edgerton, K … - Diabetes, 2002 - Am Diabetes Assoc The dose-response relationship between the hepatic sinusoidal insulin level and
glucose production by the liver is such that a half-maximally effective
concentration is at or slightly below the hormone levels seen basally after ... Cited by 30 - Related articles - BL Direct - All 4 versions
WP Pimenta, ML Santos, NS Cruz, FF Aragon, … - Brazilian Journal of Medical and Biological Research, 2003 - SciELO Brasil To identify early metabolic abnormalities in type 2 diabetes mellitus, we
measured insulin secretion, sensitivity to insulin, and hepatic insulin
extraction in 48 healthy normal glucose-tolerant Brazilians, first-degree ... Cited by 4 - Related articles - Cached - BL Direct - All 10 versions
N Katayama, SJ Hughes, SJ Persaud, PM … - Molecular and cellular endocrinology, 1995 - Elsevier Insulin secretory responses of intact and electrically permeabilised islets of
Goto-Kakizaki (GK) rats, a novel model of non-insulin dependent diabetes
mellitus, and Wistar (control) rats were compared to investigate the ... Cited by 8 - Related articles - All 5 versions
- ►diabetesjournals.org JC Henquin, N Ishiyama, M Nenquin, MA … - Diabetes, 2002 - Am Diabetes Assoc Rapid and sustained stimulation of β-cells with glucose induces biphasic
insulin secretion. The two phases appear to reflect a characteristic of
stimulus-secretion coupling in each β-cell rather than heterogeneity in ... Cited by 59 - Related articles - BL Direct - All 4 versions
