E Toschi, S Camastra, AM Sironi, A Masoni, A … - Diabetes, 2002 - Am Diabetes Assoc First-phase insulin response to intravenous glucose is impaired both in type 2
diabetic patients and in subjects at risk for the disease. Hyperglycemia can
modify β-cell response by either inhibiting or potentiating both first- ... Cited by 36 - Related articles - BL Direct - All 6 versions
CH Hsieh, YJ Hung, CT He, CH Lee, SC Hung … - Endocrine research, 2005 - ingentaconnect.com The underlying defects of type 2 diabetes are impaired insulin sensitivity and
decreased beta-cell function. In poorly controlled type 2 diabetes, the 'glucose
toxicity' further deteriorates these defects. The objective was to ... Cited by 10 - Related articles - BL Direct - All 5 versions
- ►physiology.org J Meyer, J Sturis, M Katschinski, R Arnold, B … - American Journal of Physiology- Endocrinology And …, 2002 - Am Physiological Soc Impaired glucose tolerance (IGT) and non-insulin-dependent diabetes mellitus
(NIDDM) are associated with an impaired ability of the -cell to sense and
respond to small changes in plasma glucose. The aim of this study was to ... Cited by 14 - Related articles - BL Direct - All 5 versions
RP Robertson - Transplantation proceedings, 2004 - Elsevier Various brief metabolic tests have been proposed as surrogate measures of
insulin secretory reserve, which is normally determined by the more complicated
and labor-intensive method of glucose potentiation of arginine-induced ... Cited by 6 - Related articles - All 8 versions
A Mari, S Camastra, E Toschi, A Giancaterini, … - DIABETES-NEW YORK-, 2001 - Am Diabetes Assoc The aim of this work was to develop a mathematical model describing the
functional dependence of insulin secretion on plasma glucose concentrations
during 24 h of free living. We obtained hourly central venous blood samples ... Cited by 26 - Related articles - BL Direct - All 4 versions
F Purrello, M Vetri, C Gatta, D Gullo, R Vigneri - Diabetes, 1989 - Am Diabetes Assoc We investigated the effect of 24 h of exposure to various glucose concentrations
on insulin secretion by isolated rat pancreatic islets and purified rat
beta-cells. Compared with islets cultured with standard medium (5.5 mM ... Cited by 46 - Related articles - All 5 versions
- ►endojournals.org M Stumvoll, A Fritsche, N Stefan, E Hardt, H … - Journal of Clinical Endocrinology & Metabolism, 2001 - Endocrine Soc In subjects with impaired glucose tolerance (IGT) insulin secretion is impaired.
Increased proinsulin/insulin (PI/I) ratios suggest that there is also reduced
processing of proinsulin to insulin in this condition. The PI/I ratio in ... Cited by 19 - Related articles - BL Direct - All 5 versions
- ►uc.pt [PDF] A Gastaldelli, E Ferrannini, Y Miyazaki, M … - Diabetologia, 2004 - Springer Aims/hypothesis. Both insulin resistance and beta-cell dysfunction play a role
in the transition from normal glucose tolerance (NGT) to Type 2 diabetes (T2DM)
through impaired glucose tolerance (IGT). The aim of the study was to ... Cited by 76 - Related articles - BL Direct - All 5 versions
SE Kahn, DL Leonetti, RL Prigeon, EJ Boyko … - Diabetic medicine: a journal of the British Diabetic …, 1996 - ncbi.nlm.nih.gov Disproportionate hyperproinsulinaemia is a manifestation of the beta-cell
dysfunction observed in NIDDM. However, it is unclear when this abnormality
develops and whether it predicts the development of the disease. To examine ... Cited by 22 - Related articles - BL Direct - All 2 versions
[CITATION] Recovery of function of endogenous beta-cells in streptozocin-induced diabetic rats treated …
Y Hamamoto, Y Tsuura, S Fujimoto, M Nagata … - Biochem Biophys Res Commun, 2001 Cited by 2 - Related articles
