P Gilon, MA Ravier, JC Jonas, JC Henquin - Diabetes, 2002 - Am Diabetes Assoc The mechanisms driving the pulsatility of insulin secretion in vivo and in vitro
are still unclear. Because glucose metabolism and changes in cytosolic free Ca
2+ ([Ca 2+ ] c ) in β-cells play a key role in the control of insulin ... Cited by 50 - Related articles - BL Direct - All 5 versions
- ►nih.gov R Bertram, L Satin, M Zhang, P Smolen, A … - Biophysical journal, 2004 - Elsevier Pancreatic islets of Langerhans produce bursts of electrical activity when
exposed to stimulatory glucose levels. These bursts often have a regular
repeating pattern, with a period of 10–60 s. In some cases, however, the ... Cited by 46 - Related articles - BL Direct - All 15 versions
M Ravier, J Sehlin, J Henquin - Diabetologia, 2002 - Springer Aims/hypothesis. In normal mouse islets, glucose in- duces synchronous
cytoplasmic [Ca 2+ ] i oscillations in beta cells and pulses of insulin
secretion. We investi- gated whether this fine regulation of islet function ... Cited by 22 - Related articles - BL Direct - All 3 versions
JC Jonas, P Gilon, JC Henquin - Diabetes, 1998 - Am Diabetes Assoc An increase in cytoplasmic Ca 2 + in -cells is a key step in glucose-induced
insulin secretion. However, whether changes in cytoplasmic free Ca 2+ ([Ca 2+ ]
i ) directly regu- late secretion remains disputed. This question was ... Cited by 63 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org LL Kjems, MA Ravier, JC Jonas, JC Henquin - Diabetes, 2002 - Am Diabetes Assoc That oscillations of the cytoplasmic free Ca 2+ concentration ([Ca 2+ ] i ) in
ß-cells induce oscillations of insulin secretion is not disputed, but whether
metabolism-driven oscillations of secretion can occur in the absence of [Ca ... Cited by 13 - Related articles - BL Direct - All 6 versions
- ►jbc.org SK Jung, LM Kauri, WJ Qian, RT Kennedy - Journal of Biological Chemistry, 2000 - ASBMB Micron-sized sensors were used to monitor glucose and oxygen levels in the
extracellular space of single islets of Langerhans in real-time. At 10 mM
glucose, oscillations in intraislet glucose concentration were readily ... Cited by 62 - Related articles - BL Direct - All 3 versions
P Bergsten, J Westerlund, P Liss, PO … - Diabetes, 2002 - Am Diabetes Assoc The role of metabolism in the generation of plasma insulin oscillations was
investigated by simultaneous in vivo recordings of oxygen tension (pO 2 ) in the
endocrine and exocrine pancreas and portal blood insulin concentrations in ... Cited by 17 - Related articles - BL Direct - All 4 versions
M Düfer, D Haspel, P Krippeit-Drews, L … - Diabetologia, 2004 - Springer Aims/hypothesis. SUR1(ABCC8) −/− mice lacking func- tional KATP channels are
an appropriate model to test the significance of KATP channels in beta-cell
function. We examined how this gene deletion interferes with ... Cited by 26 - Related articles - BL Direct - All 4 versions
GM Dahlgren, LM Kauri, RT Kennedy - BBA-General Subjects, 2005 - Elsevier Glucose induces complex patterns of oscillations in intracellular Ca 2+
concentration ([Ca 2+ ] i ), metabolism and secretion in islets of Langerhans
including “slow” and “fast” pulses with period of 2–5 min and ... Cited by 19 - Related articles - All 3 versions
E Gylfe, M Ahmed, P Bergsten, H Dansk, O … - Upsala journal of medical sciences, 2000 - ncbi.nlm.nih.gov 1: Ups J Med Sci. 2000;105(2):35-51. Signaling underlying pulsatile insulin
secretion. Gylfe E, Ahmed M, Bergsten P, Dansk H, Dyachok ... Cited by 18 - Related articles - BL Direct
