- ►diabetesjournals.org RT Kennedy, LM Kauri, GM Dahlgren, SK … - Diabetes, 2002 - Am Diabetes Assoc Whereas the mechanisms underlying oscillatory insulin secretion remain unknown,
several models have been advanced to explain if they involve generation of
metabolic oscillations in β-cells. Evidence, including measurements of ... Cited by 29 - Related articles - BL Direct - All 5 versions
RT Kennedy, LM Kauri, GM Dahlgren, SK … - Diabetes, 2002 - Am Diabetes Assoc Whereas the mechanisms underlying oscillatory insulin secretion remain unknown,
several models have been advanced to explain if they involve generation of meta-
bolic oscillations in -cells. Evidence, including mea- surements of oxygen ... Cited by 11 - Related articles - All 2 versions
- ►diabetesjournals.org EK Ainscow, GA Rutter - Diabetes, 2002 - Am Diabetes Assoc Normal glucose-stimulated insulin secretion is pulsatile, but the molecular
mechanisms underlying this pulsatility are poorly understood. Oscillations in
the intracellular free [ATP]/[ADP] ratio represent one possible mechanism ... Cited by 37 - Related articles - BL Direct - All 5 versions
- ►physiology.org LE Fridlyand, N Tamarina, LH Philipson - American Journal of Physiology- Endocrinology And …, 2003 - Am Physiological Soc We have developed a detailed mathematical model of ionic flux in -cells that
includes the most essential channels and pumps in the plasma membrane. This
model is coupled to equations describing Ca 2+ , inositol ... Cited by 37 - Related articles - BL Direct - All 4 versions
GM Dahlgren, LM Kauri, RT Kennedy - BBA-General Subjects, 2005 - Elsevier Glucose induces complex patterns of oscillations in intracellular Ca 2+
concentration ([Ca 2+ ] i ), metabolism and secretion in islets of Langerhans
including “slow” and “fast” pulses with period of 2–5 min and ... Cited by 19 - Related articles - All 3 versions
- ►jbc.org L Juntti-Berggren, DL Webb, POG Arkhammar … - Journal of Biological Chemistry, 2003 - ASBMB Glucose stimulation of pancreatic -cells causes oscillatory influx of Ca 2+ ,
leading to pulsatile insulin secretion. We have proposed that this is due to
oscillations of glycolysis and the ATP/ADP ratio, which modulate the ... Cited by 16 - Related articles - BL Direct - All 4 versions
- ►jbc.org SK Jung, LM Kauri, WJ Qian, RT Kennedy - Journal of Biological Chemistry, 2000 - ASBMB Micron-sized sensors were used to monitor glucose and oxygen levels in the
extracellular space of single islets of Langerhans in real-time. At 10 mM
glucose, oscillations in intraislet glucose concentration were readily ... Cited by 62 - Related articles - BL Direct - All 3 versions
DS Luciani, S Misler, KS Polonsky - The Journal of Physiology, 2006 - Physiological Soc Exposure of pancreatic islets of Langerhans to physiological concentrations of
glucose leads to secretion of insulin in an oscillatory pattern. The
oscillations in insulin secretion are associated with oscillations in ... Cited by 26 - Related articles - BL Direct - All 7 versions
H Ortsäter, P Liss, PE Lund, KEO Åkerman, P … - Diabetologia, 2000 - Springer Insulin is released in 4±5 min pulses from isolated is- lets [1]. The rhythmic
release of the hormone is deci- sive for the appearance of plasma insulin
oscillations [2,3], which are important for the blood glucose low- ering ... Cited by 28 - Related articles - BL Direct - All 4 versions
S Lenzen, M Lerch, T Peckmann, M Tiedge - BBA-General Subjects, 2000 - Elsevier Glucose induces slow oscillations of the cytoplasmic Ca 2+ concentration in
pancreatic β-cells. In order to elucidate the mechanisms responsible for the
slow [Ca 2+ ] i oscillations the effects of various nutrient insulin ... Cited by 22 - Related articles - All 5 versions
