- ►diabetesjournals.org EK Ainscow, GA Rutter - Diabetes, 2002 - Am Diabetes Assoc Normal glucose-stimulated insulin secretion is pulsatile, but the molecular mechanisms underlying
this pulsatility are poorly understood. Oscillations in the intracellular free [ATP]/[ADP] ratio represent
one possible mechanism because they would be expected to cause fluctuations in ATP- ... Cited by 37 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org RT Kennedy, LM Kauri, GM Dahlgren, SK Jung - Diabetes, 2002 - Am Diabetes Assoc Whereas the mechanisms underlying oscillatory insulin secretion remain unknown, several models
have been advanced to explain if they involve generation of metabolic oscillations in β-cells.
Evidence, including measurements of oxygen consumption, glucose consumption, ... Cited by 29 - Related articles - BL Direct - All 5 versions
DS Luciani, S Misler, KS Polonsky - The Journal of Physiology, 2006 - Physiological Soc Exposure of pancreatic islets of Langerhans to physiological concentrations of glucose leads
to secretion of insulin in an oscillatory pattern. The oscillations in insulin secretion are associated
with oscillations in cytosolic Ca 2+ concentration ([Ca 2+ ] c ). Evidence suggests that the ... Cited by 26 - Related articles - BL Direct - All 7 versions
- ►nih.gov [PDF] P Detimary, P Gilon, JC Henquin - Biochemical Journal, 1998 - pubmedcentral.nih.gov In pancreatic β cells, the increase in the ATP\ADP ratio that follows a stimulation by glucose is
thought to play an important role in the Ca#+-dependent increase in insulin secretion. Here we
have investigated the possible interactions between Ca#+ and adenine nucleotides in ... Cited by 92 - Related articles - BL Direct - All 6 versions
RT Kennedy, LM Kauri, GM Dahlgren, SK Jung - Diabetes, 2002 - Am Diabetes Assoc Whereas the mechanisms underlying oscillatory insulin secretion remain unknown, several models
have been advanced to explain if they involve generation of meta- bolic oscillations in -cells.
Evidence, including mea- surements of oxygen consumption, glucose consump- tion, ... Cited by 11 - Related articles - All 2 versions
[CITATION] Glucose-induced ATP microdomains in single islet beta-cells
P Krippeit-Drews, M Düfer, G Drews - Biochemical and Biophysical Research …, 2000 - Elsevier Insulin secretion in normal B-cells is pulsatile, a consequence of oscillations in the cell membrane
potential (MP) and cytosolic calcium activity ([Ca 2+ ] c ). We simultaneously monitored
glucose-induced changes in [Ca 2+ ] c and in the mitochondrial membrane potential ΔΨ, ... Cited by 56 - Related articles - BL Direct - All 6 versions
- ►psu.edu [PDF] R Bertram, A Sherman - Bulletin of mathematical biology, 2004 - Springer Insulin-secreting β-cells, located within the pancreatic islets of Langerhans, are excitable cells
that produce regular bursts of action potentials when stimulated by glucose. This system has
been the focus of mathematical investigation for two decades, spawning an array of ... Cited by 34 - Related articles - All 6 versions
- ►physiology.org LE Fridlyand, N Tamarina, LH … - American Journal of …, 2003 - Am Physiological Soc We have developed a detailed mathematical model of ionic flux in -cells that includes the most
essential channels and pumps in the plasma membrane. This model is coupled to equations
describing Ca 2+ , inositol 1,4,5-trisphosphate (IP 3 ), ATP, and Na + homeostasis, ... Cited by 37 - Related articles - BL Direct - All 4 versions
H Ortsäter, P Liss, PE Lund, KEO Åkerman, P Bergsten - Diabetologia, 2000 - Springer Insulin is released in 4±5 min pulses from isolated is- lets [1]. The rhythmic release of the hormone
is deci- sive for the appearance of plasma insulin oscillations [2,3], which are important for the
blood glucose low- ering effect of the hormone [4, 5, 6]. Despite the im- portance of ... Cited by 28 - Related articles - BL Direct - All 4 versions
