P Bergsten - Diabetes, 2002 - Am Diabetes Assoc A model for the relationship between ionic and metabolic oscillations and plasma insulin oscillations
is presented. It is argued that the pancreatic β-cell in vivo displays two intrinsic frequencies that
are important for the regulation of plasma insulin oscillations. The rapid oscillatory activity ... Cited by 23 - Related articles - BL Direct - All 6 versions
P Bergsten, J Westerlund, P Liss, PO Carlsson - Diabetes, 2002 - Am Diabetes Assoc The role of metabolism in the generation of plasma insulin oscillations was investigated by simultaneous
in vivo recordings of oxygen tension (pO 2 ) in the endocrine and exocrine pancreas and portal
blood insulin concentrations in the anesthetized rat. At the start of the experiment, the ... Cited by 17 - Related articles - BL Direct - All 4 versions
P Bergsten, NN Foundation, FE … - Diabetes/Metabolism … - interscience.wiley.com Plasma insulin displays 5-10 min oscillations. In Type 2 diabetes the regularity of the oscillations
disappears, which may lead to insulin receptor down-regulation and glucose intolerance and
explain why pulsatile delivery of the hormone has a greater hypoglycemic effect than ... Cited by 38 - Related articles - BL Direct - All 4 versions
- ►nih.gov CS Nunemaker, R Bertram, A Sherman, K Tsaneva- … - Biophysical journal, 2006 - Elsevier Pancreatic islets of Langerhans display complex intracellular calcium changes in response to
glucose that include fast (seconds), slow ( 5 min), and mixed fast/slow oscillations; the slow and
mixed oscillations are likely responsible for the pulses of plasma insulin observed in vivo. ... Cited by 16 - Related articles - BL Direct - All 15 versions
- ►rupress.org T Rose, S Efendic, M Rupnik - Journal of General Physiology, 2007 - jgp.rupress.org The Goto Kakizaki (GK) rat is a widely used animal model to study defective glucose-stimulated
insulin release in type-2 diabetes (T2D). As in T2D patients, the expression of several proteins
involved in Ca 2+ -dependent exocytosis of insulin-containing large dense-core vesicles ... Cited by 10 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org L Sha, J Westerlund, JH Szurszewski, P Bergsten - Diabetes, 2001 - Am Diabetes Assoc Neuron activity and insulin release were measured simultaneously from 33 preparations of intrapancreatic
canine ganglia and pancreatic parenchyma adjacent to the ganglia. The electrical activity of
single neurons of the ganglia was recorded with intracellular microelectrodes, and insulin ... Cited by 20 - Related articles - BL Direct - All 4 versions
- ►aspetjournals.org G Liu, N Hilliard, GH Hockerman - Molecular pharmacology, 2004 - ASPET The link between Ca 2+ influx through the L-type calcium channels Ca v 1.2 or Ca v 1.3 and
glucose- or KCl-induced [Ca 2+ ] i mobilization in INS-1 cells was assessed using the calcium
indicator indo-1. Cells responded to 18 mM glucose or 50 mM KCl stimulation with ... Cited by 13 - Related articles - BL Direct - All 5 versions
[CITATION] Taborsky GJ Jr. Pancreatic somatostatin is a mediator of glucagon inhibition by …
D Dey, B Pandey, A Nag, I Peng, M Chovatia, P … - American Journal of …, 2004 - Elsevier BLX-1002 is a water-soluble, orally active, modified single amino acid derivative with no structural
resemblance with any existing compounds. When given orally in obese diabetic db/db orob/ob
mice, at a dose of 50 mg/kg body weight per day, it was able to reduce blood glucose by ... Cited by 2 - Related articles - All 3 versions
