- ►diabetesjournals.org RN Bergman, M Ader, K Huecking, G Van … - Diabetes, 2002 - Am Diabetes Assoc Only in the last decade did modeling studies predict, and knockout experiments
confirm, that type 2 diabetes is a "2-hit" disease in which insulin resistance
is necessarily accompanied by ß-cell defect(s) preventing the compensatory ... Cited by 171 - Related articles - BL Direct - All 4 versions
E Ferrannini, A Mari - Diabetologia, 2004 - Springer The importance of both insulin resistance and beta cell dysfunction in the
pathogenesis of glucose intolerance is widely recognised. Also popular is the
concept that beta cell secretory function must be viewed in the context of ... Cited by 76 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] RN Bergman, LS Phillips, C Cobelli - Journal of Clinical Investigation, 1981 - pubmedcentral.nih.gov A B S TRA CT The quantitative contributions of pan- creatic responsiveness and
insulin sensitivity to glu- cose tolerance were measured using the "minimal
modeling technique" in 18 lean and obese subjects (88-206% ideal body wt). ... Cited by 594 - Related articles - All 8 versions
- ►childrenshospitalla.org [PDF] SD Mittelman, GW Van Citters, SP Kim, DA … - Diabetes, 2000 - Am Diabetes Assoc Central adiposity is highly correlated with insulin resistance, which is an
important risk factor for type 2 diabetes and other chronic diseases. However,
in normal individuals, central adiposity can be tolerated for many years ... Cited by 80 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org RC Bonadonna, M Stumvoll, A Fritsche, M … - Diabetes, 2003 - Am Diabetes Assoc We adapted a minimal model to assess β-cell function during a hyperglycemic
glucose clamp and to uncover peculiar aspects of the relationship among β-cell
function, plasma glucose, and insulin sensitivity (IS) in offspring of ... Cited by 46 - Related articles - BL Direct - All 6 versions
M Stumvoll, A Mitrakou, W Pimenta, T Jenssen … - Diabetes Care, 2000 - Am Diabetes Assoc T he oral glucose tolerance test (OGTT) is a widely used pro cedu re that was
originally developed to classify carbo- hydrate tolerance (1). However, because
plasma glucose and insulin responses dur- ing this test reflect the ability ... Cited by 380 - Related articles - BL Direct - All 5 versions
SE Kahn - Diabetologia, 2003 - Springer The relative contributions of insulin resistance and be- ta-cell dysfunction to
the pathophysiology of Type 2 diabetes have been debated extensively. The
concept that a feedback loop governs the interaction of the in- ... Cited by 515 - Related articles - BL Direct - All 6 versions
- ►physiology.org G Pacini, K Thomaseth, B Ahren - American Journal of Physiology- Endocrinology And …, 2001 - Am Physiological Soc To study the contributions of insulin-dependent vs. insulin-independent
mechanisms to intravenous glucose tolerance (K G ), 475 experiments in mice were
performed. An intravenous glucose bolus was given either alone or with ... Cited by 64 - Related articles - BL Direct - All 4 versions
RL Prigeon, SE Kahn, D Porte… - Metabolism, 1995 - Elsevier To determine the relative contributions of changes in glucose effectiveness,
B-cell function, and insulin sensitivity to changes in glucose tolerance upon
exercise cessation in regularly exercising individuals, we studied seven ... Cited by 28 - Related articles - BL Direct - All 5 versions
