- ►diabetesjournals.org A Mari, A Tura, A Gastaldelli, E Ferrannini - Diabetes, 2002 - Am Diabetes Assoc We developed a mathematical model of the glucose control of insulin secretion
capable of quantifying β-cell function from a physiological meal test. The
model includes a static control, ie, a secretion component that is a ... Cited by 64 - Related articles - BL Direct - All 4 versions
- ►physiology.org A Mari, O Schmitz, A Gastaldelli, T … - American Journal of Physiology- Endocrinology And …, 2002 - Am Physiological Soc We investigated -cell function and its relationship to insulin sensitivity in 17
normal volunteers. For insulin secretion (derived by C-peptide deconvolution), a
mathematical model was applied to 24-h triple-meal tests (MT) as well as ... Cited by 89 - Related articles - BL Direct - All 5 versions
A Mari, S Camastra, E Toschi, A Giancaterini, … - DIABETES-NEW YORK-, 2001 - Am Diabetes Assoc The aim of this work was to develop a mathematical model describing the
functional dependence of insulin secretion on plasma glucose concentrations
during 24 h of free living. We obtained hourly central venous blood samples ... Cited by 26 - Related articles - BL Direct - All 4 versions
- ►endojournals.org R Hovorka, L Chassin, SD Luzio, R Playle, … - Journal of Clinical Endocrinology & Metabolism, 1998 - Endocrine Soc A model-based method was developed to quantify pancreatic ß-cell responsiveness
during a meal tolerance test (MTT). C peptide secretion was related in a linear
fashion to glucose concentration, whereas the standard population model was ... Cited by 40 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org B Ahrén, JJ Holst, A Mari - Diabetes Care, 2003 - Am Diabetes Assoc RESULTS—GLP-1 markedly augmented insulin secretion, despite lower glucose.
Total insulin secretion was 29.7 ± 4.2 nmol/m 2 with GLP-1 versus 21.0 ± 1.6
nmol/m 2 with saline (P = 0.048). GLP-1 increased the dose-response ... Cited by 28 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org E Breda, MK Cavaghan, G Toffolo, KS … - Diabetes, 2001 - Am Diabetes Assoc The simultaneous assessment of quantitative indexes of insulin secretion and
action in a single individual is important when quantifying their relative role
in the evolution of glucose tolerance in different physiopathological ... Cited by 98 - Related articles - BL Direct - All 4 versions
E Ferrannini, A Mari - Diabetologia, 2004 - Springer The importance of both insulin resistance and beta cell dysfunction in the
pathogenesis of glucose intolerance is widely recognised. Also popular is the
concept that beta cell secretory function must be viewed in the context of ... Cited by 76 - Related articles - BL Direct - All 4 versions
A Cretti, M Lehtovirta, E Bonora, B Brunato … - European Journal of Clinical Investigation, 2001 - interscience.wiley.com DesignFifty-six subjects were studied. A minimal analogic model of β-cell
secretion during the OGTT was applied to all OGTTs (see below). The amount of
insulin secreted over 120' in response to oral glucose (OGTT-ISR; Insulin ... Cited by 43 - Related articles - BL Direct - All 4 versions
- ►endojournals.org E Ferrannini, A Gastaldelli, Y Miyazaki, M … - Journal of Clinical Endocrinology & Metabolism, 2005 - Endocrine Soc The nature of the progressive ß-cell failure occurring as normal glucose
tolerant (NGT) individuals progress to type 2 diabetes (T2DM) is incompletely
understood. We measured insulin sensitivity (by a euglycemic insulin clamp) ... Cited by 131 - Related articles - All 5 versions
E Van Cauter, F Mestrez, J Sturis, KS … - Diabetes, 1992 - Am Diabetes Assoc Insulin secretion rates can be accurately estimated from plasma C-peptide levels
with a two-compartment model for C-peptide distribution and degradation. In
previous studies, the kinetic parameters of C-peptide clearance were ... Cited by 281 - Related articles - All 4 versions
