A Fritsche, A Madaus, N Stefan, O Tschritter, … - Diabetes, 2002 - Am Diabetes Assoc The aim of the present study was to examine the relationships among β-cell
function, proinsulin conversion to insulin, and age. We studied insulin and
proinsulin secretion in nondiabetic subjects during an oral glucose ... Cited by 39 - Related articles - BL Direct - All 5 versions
- ►endojournals.org M Stumvoll, A Fritsche, N Stefan, E Hardt, H … - Journal of Clinical Endocrinology & Metabolism, 2001 - Endocrine Soc In subjects with impaired glucose tolerance (IGT) insulin secretion is impaired.
Increased proinsulin/insulin (PI/I) ratios suggest that there is also reduced
processing of proinsulin to insulin in this condition. The PI/I ratio in ... Cited by 19 - Related articles - BL Direct - All 5 versions
KC Chiu, NP Lee, P Cohan, LM Chuang - Clinical Endocrinology, 2000 - ingentaconnect.com OBJECTIVE As type 2 diabetes results from an imbal- ance between insulin
sensitivity and beta cell func- tion, either or both may worsen with age.
However, existing data are controversial on the effect of ageing on both ... Cited by 33 - Related articles - BL Direct - All 4 versions
M Shimizu, S Kawazu, S Tomono, T Ohno, T … - Diabetes Care, 1996 - Am Diabetes Assoc OBJECTIVE: To determine the secretion of insulin, C-peptide, and proinsulin
after oral glucose loading in healthy elderly subjects compared with middle-aged
subjects with and without obesity and with NIDDM. RESEARCH DESIGN AND ... Cited by 36 - Related articles - BL Direct - All 5 versions
- ►endojournals.org H Larsson, B Ahren - Journal of Clinical Endocrinology & Metabolism, 1999 - Endocrine Soc Proinsulin release is increased relative to insulin secretion in subjects with
type 2 diabetes, indicative of islet dysfunction. However, it has not been
conclusively shown whether there is an increased relative proinsulin ... Cited by 28 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org AJG Hanley, RD'Agostino, LE Wagenknecht, … - Diabetes, 2002 - Am Diabetes Assoc Previous studies have indicated that β-cell dysfunction predicts the
development of diabetes, although it is unknown whether the use of combinations
of insulin secretory measures further improves prediction. The Insulin ... Cited by 46 - Related articles - BL Direct - All 4 versions
N Stefan, A Fritsche, A Madaus, H Häring, M … - Diabetologia, 2000 - Springer Increased concentrations of non-esterified fatty acid (NEFA) are believed to
play a part in the pathogene- sis of Type II (non-insulin-dependent) diabetes
melli- tus by inhibiting insulin stimulated peripheral glucose uptake and ... Cited by 7 - Related articles - BL Direct - All 4 versions
SE Kahn, DL Leonetti, RL Prigeon, EJ Boyko … - Diabetic medicine: a journal of the British Diabetic …, 1996 - ncbi.nlm.nih.gov Disproportionate hyperproinsulinaemia is a manifestation of the beta-cell
dysfunction observed in NIDDM. However, it is unclear when this abnormality
develops and whether it predicts the development of the disease. To examine ... Cited by 22 - Related articles - BL Direct - All 2 versions
RP Robertson - Transplantation proceedings, 2004 - Elsevier Various brief metabolic tests have been proposed as surrogate measures of
insulin secretory reserve, which is normally determined by the more complicated
and labor-intensive method of glucose potentiation of arginine-induced ... Cited by 6 - Related articles - All 8 versions
