- ►diabetesjournals.org CB Wollheim, P Maechler - Diabetes, 2002 - Am Diabetes Assoc The β-cell mitochondria are known to generate metabolic coupling factors, or
messengers, that mediate plasma membrane depolarization and the increase in
cytosolic Ca 2+ , the triggering event in glucose-stimulated insulin ... Cited by 43 - Related articles - BL Direct - All 4 versions
- ►nih.gov P Maechler, CB Wollheim - The Journal of Physiology, 2000 - Physiological Soc Glucose-induced insulin secretion is determined by signals generated in the
mitochondria. The elevation of ATP is necessary for the membrane-dependent
increase in cytosolic Ca 2+ , the main trigger of insulin exocytosis. Beta ... Cited by 58 - Related articles - BL Direct - All 8 versions
- ►jbc.org YQ Liu, JA Moibi, JL Leahy - Journal of Biological Chemistry, 2004 - ASBMB In islet -cells, the high expression of pyruvate carboxylase and the functional
importance of the downstream anaplerosis pathways result in a unique
characteristic whereby high glucose and fatty acids both increase ... Cited by 15 - Related articles - BL Direct - All 4 versions
[CITATION] P. in't Veld, G
Y Heremans, M Van De Casteele - Gradwohl, P. Serup, O. Madsen, D. Pipeleers, and H. …, 2002 Cited by 3 - Related articles
P Maechler - Current Opinion in Investigational Drugs, 2003 - biomedcentral.com Coupling of glucose entry to insulin secretion in pancreatic β-cells depends on
numerous intracellular metabolic steps. In this process, mitochondria play a
central role, and defects in this organelle are associated with impaired ... Cited by 11 - Related articles - View as HTML - BL Direct - All 4 versions
P Maechler - Cellular and molecular life sciences, 2002 - Springer Abstract. Mitochondrial metabolism is crucial for the coupling of glucose
recognition to the exocytosis of the insulin granules. This is illustrated by in
vitro and in vivo observations discussed in the present review. Mitochon- ... Cited by 43 - Related articles - BL Direct - All 5 versions
Y Shimajiri, M Shimabukuro, T Tomoyose, H … - Biochemical and Biophysical Research …, 2003 - Elsevier We previously reported that a missense mutation at codon 121 (CGG Arg to TGG Trp
, R121W) of PAX4 may be associated with the onset of type 2 diabetes in
Japanese. In this study, we determined the frequency of the R121W mutation ... Cited by 10 - Related articles - BL Direct - All 4 versions
- ►unige.ch [PDF] P Maechler, S Carobbio, B Rubi - International Journal of Biochemistry and Cell Biology, 2006 - Elsevier Pancreatic beta-cells are unique neuroendocrine cells displaying the peculiar
feature of responding to nutrients, principally glucose, as primary stimulus.
This requires translation of a metabolic substrate into intracellular ... Cited by 29 - Related articles - All 7 versions
- ►jbc.org BR Gauthier, T Brun, EJ Sarret, H Ishihara, … - Journal of Biological Chemistry, 2004 - ASBMB Mutations in the transcription factor IPF1/PDX1 have been associated with type 2
diabetes. To elucidate -cell dysfunction, PDX1 was suppressed by transduction of
rat islets with an adenoviral construct encoding a dominant negative form ... Cited by 48 - Related articles - BL Direct - All 5 versions
JC Matthews, KJ Anderson - Current Opinion in Clinical Nutrition & Metabolic Care, 2002 - journals.lww.com Complementary DNAs that encode proteins capable of biochemically defined system
A-, N-, asc-, and T-like activities have been cloned. Functional expression and
localization analyses of these proteins have revealed significant ... Cited by 12 - Related articles - BL Direct - All 2 versions
