- ►diabetesjournals.org MG Roper, W Qian, BB Zhang, RN Kulkarni, … - Diabetes, 2002 - Am Diabetes Assoc L-783,281, an antidiabetic fungal metabolite that has previously been shown to
activate insulin signaling in CHO cells, was tested for its effect on
intracellular Ca 2+ ([Ca 2+ ] i ) and insulin secretion in single mouse ... Cited by 23 - Related articles - BL Direct - All 5 versions
J Westerlund, BA Wolf, P Bergsten - Diabetes, 2002 - Am Diabetes Assoc An insulin-mimetic compound (L-783,281) was used in an attempt to determine the
role of the β-cell insulin receptor (IR) on insulin release. Islets were
isolated from C57Bl/6j mice and cultured for 1 to 4 days. Insulin release ... Cited by 8 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org FA Khan, PB Goforth, M Zhang, LS Satin - Diabetes, 2001 - Am Diabetes Assoc Insulin is known to regulate pancreatic β-cell function through the activation
of cell surface insulin receptors, phosphorylation of insulin receptor substrate
(IRS)-1 and -2, and activation of phosphatidylinositol (PI) 3-kinase. ... Cited by 69 - Related articles - BL Direct - All 4 versions
- ►endocrinology-journals.org [PDF] WS Zawalich, GJ Tesz, KC Zawalich - Journal of Endocrinology, 2002 - Soc Endocrinology We examined the effects of phosphatidylinositol 3-kinase (PI3K) inhibition by
wortmannin or LY294002 on glucose-induced secretion from mouse islets. Islets
were collagenase isolated and perifused or subjected to Western blot ... Cited by 28 - Related articles - BL Direct - All 6 versions
GG Xu, ZY Gao, PD Borge Jr, PA Jegier, RA … - Biochemistry, 2000 - ncbi.nlm.nih.gov The insulin receptor signaling pathway is present in beta-cells and is believed
to be important in beta-cell function. We show here that insulin directly
regulates beta-cell function in isolated rodent islets. Long-term insulin ... Cited by 41 - Related articles - BL Direct - All 3 versions
- ►ncue.edu.tw [PDF] SJ Persaud, H Asare-Anane, PM Jones - FEBS letters, 2002 - Elsevier There is no consensus on the role of insulin secreted from pancreatic β-cells
in regulating its own secretion, either in rodent islets or in human islets. We
have now investigated whether there is an autocrine signalling role for ... Cited by 46 - Related articles - All 7 versions
PD Borge, BA Wolf - Journal of Biological Chemistry, 2003 - ASBMB We have previously characterized an insulin receptor substrate 1
(IRS-1)-overexpressing β-cell line. These β-cells demonstrated elevated
fractional insulin secretion and elevated cytosolic Ca 2+ levels compared ... Cited by 20 - Related articles - BL Direct - All 4 versions
PD Borge, J Moibi, SR Greene, M Trucco, RA … - Diabetes, 2002 - Am Diabetes Assoc Glucose is the main physiological secretagogue for insulin secretion by
pancreatic β-cells, and the major biochemical mechanisms involved have been
elucidated. In particular, an increase in intracellular calcium is ... Cited by 11 - Related articles - BL Direct - All 3 versions
- ►endojournals.org WS Zawalich, KC Zawalich - Endocrinology, 2000 - Endocrine Soc Wortmannin (5–100 nM), a specific phosphatidyinositol 3-kinase inhibitor,
augmented 8 mM glucose-induced insulin secretion from control Sprague Dawley rat
islets in a dose-dependent manner. This effect persisted after its removal ... Cited by 34 - Related articles - BL Direct - All 3 versions
CA Aspinwall, WJ Qian, MG Roper, RN … - Journal of Biological Chemistry, 2000 - ASBMB The signaling pathway by which insulin stimulates insulin secretion and
increases in intracellular free Ca 2+ concentration ([Ca 2+ ] i ) in isolated
mouse pancreatic β-cells and clonal β-cells was investigated. Application ... Cited by 114 - Related articles - BL Direct - All 3 versions
