J Westerlund, BA Wolf, P Bergsten - Diabetes, 2002 - Am Diabetes Assoc An insulin-mimetic compound (L-783,281) was used in an attempt to determine the role of the
β-cell insulin receptor (IR) on insulin release. Islets were isolated from C57Bl/6j mice and cultured
for 1 to 4 days. Insulin release from individual islets perifused in the presence of 3 mmol/l ... Cited by 8 - Related articles - BL Direct - All 5 versions
PD Borge, J Moibi, SR Greene, M Trucco, RA Young, Z … - Diabetes, 2002 - Am Diabetes Assoc Glucose is the main physiological secretagogue for insulin secretion by pancreatic β-cells, and
the major biochemical mechanisms involved have been elucidated. In particular, an increase
in intracellular calcium is important for insulin exocytosis. More recently, it has become ... Cited by 11 - Related articles - BL Direct - All 3 versions
MJ Dunne - Diabetic Medicine, 2000 - ingentaconnect.com In 1968, reports of the ®rst microelectrode recordings of insulin-secreting cells were
published. Thirty years later it is now established that electrical responses of b-cells play a critical
role in stimulus-secretion coupling. It is now also clear that defects in ion channel genes ... Cited by 5 - Related articles - All 4 versions
- ►diabetesjournals.org MG Roper, W Qian, BB Zhang, RN Kulkarni, CR Kahn, … - Diabetes, 2002 - Am Diabetes Assoc L-783,281, an antidiabetic fungal metabolite that has previously been shown to activate insulin
signaling in CHO cells, was tested for its effect on intracellular Ca 2+ ([Ca 2+ ] i ) and insulin secretion
in single mouse pancreatic β-cells. Application of 10 μmol/l L-783,281 for 40 s to isolated ... Cited by 23 - Related articles - BL Direct - All 5 versions
Y Hamada, H Ikegami, H Ueda, Y Kawaguchi, E … - Metabolism, 2001 - Elsevier To clarify the mechanisms of impaired insulin secretion in Nagoya-Shibata-Yasuda (NSY)
mice, an inbred strain of mice with spontaneous development of type 2 (non[ndash
]insulin-dependent) diabetes mellitus, the insulin response to glucose (5.5 to 27.8 ... Cited by 7 - Related articles - BL Direct - All 6 versions
H Toba, E Gomyo, S Miki, T Shimizu, A … - Clinical and …, 2006 - pt.wkhealth.com 1. Hyperinsulinaemia has been reported to be an independent risk factor for cardiovascular
diseases. Insulin stimulates both the phosphatidylinositol 3-kinase (PI3-K)/Akt and mitogen-activated
protein kinase (MAPK) pathways. To investigate the direct effects of insulin on vascular ... Cited by 8 - Related articles - BL Direct - All 9 versions
[CITATION] Pharmacological evidence that endothelium-derived relaxing factor is NO: use of …
HJ Goren - Current Diabetes Reviews, 2005 - ingentaconnect.com Abstract: Diabetes is on the increase worldwide and greater than 90% are type 2. There are two
features to type 2 diabetes: muscle, fat and liver tissues are insulin resistant and β cells lose
the ability to secrete insulin. Prior to developing diabetes, however, insulin resistant ... Related articles - BL Direct - All 2 versions
