- ►diabetesjournals.org R Nesher, E Cerasi - Diabetes, 2002 - Am Diabetes Assoc The cellular and molecular mechanisms of insulin secretion are being intensively
investigated, yet most researchers are seemingly unaware of the complexity of
the dynamic regulation of the secretion. In this article, we summarize ... Cited by 55 - Related articles - BL Direct - All 5 versions
- ►physiology.org SG Straub, GWG Sharp - American Journal of Physiology- Cell Physiology, 2004 - Am Physiological Soc The biphasic secretory response of pancreatic -cells to abrupt and sustained
exposure to glucose is well documented. Some of the ATP-sensitive K + (K ATP )
channel-dependent mechanisms underlying the first phase of insulin release ... Cited by 22 - Related articles - All 3 versions
R NESHER, E CERASI - Endocrinology, 1987 - Endocrine Soc The dynamics of insulin release were investigated in vitro in order to determine
the regulatory processes governing its biphasic shape. When subjected to a
square wave glucose stimulation, the isolated perfused rat pancreas ... Cited by 46 - Related articles - All 4 versions
E Cerasi, G Fick, M Rudemo - Eur J Clin Invest, 1974 - interscience.wiley.com Abstract. The dynamics of the insulin response to intravenously administered
glucose were studied in man. It was shown that (a) insulin response to prolonged
stimulation is biphasic; (b) if the glucose stimulus is repeated with short ... Cited by 65 - Related articles - All 2 versions
R Nesher, L Waldman, E Cerasi - Diabetologia, 1984 - Springer Summary. The isolated perfused rat pancreas was stimulated sequentially with
arginine or glucose to analyze the time-de- pendent modulation of insulin
release. A 10-min perfusion with arginine (5.0 mmol/1) induced 75% ... Cited by 16 - Related articles - All 3 versions
E Breda, G Toffolo, KS Polonsky, C Cobelli - Diabetes, 2002 - Am Diabetes Assoc The availability of quantitative indexes describing β-cell function in normal
life conditions is important for the characterization of impaired mechanisms of
insulin secretion in pathophysiological states. Recently, an oral C-peptide ... Cited by 25 - Related articles - BL Direct - All 5 versions
A Mari, S Camastra, E Toschi, A Giancaterini, … - DIABETES-NEW YORK-, 2001 - Am Diabetes Assoc The aim of this work was to develop a mathematical model describing the
functional dependence of insulin secretion on plasma glucose concentrations
during 24 h of free living. We obtained hourly central venous blood samples ... Cited by 26 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org JC Henquin, N Ishiyama, M Nenquin, MA … - Diabetes, 2002 - Am Diabetes Assoc Rapid and sustained stimulation of β-cells with glucose induces biphasic
insulin secretion. The two phases appear to reflect a characteristic of
stimulus-secretion coupling in each β-cell rather than heterogeneity in ... Cited by 59 - Related articles - BL Direct - All 4 versions
- ►nih.gov X Jing, DQ Li, CS Olofsson, A Salehi, VV … - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig Concerted activation of different voltage-gated Ca 2+ channel isoforms may
determine the kinetics of insulin release from pancreatic islets. Here we have
elucidated the role of R-type Ca V 2.3 channels in that process. A 20% ... Cited by 64 - Related articles - All 9 versions
R Nesher, B Tuch, C Hage, J Levy, E Cerasi - Diabetologia, 1984 - Springer Summary. Brief stimulation of the pancreas with arginine causes a refractory
state which reduces the insulin response to subsequent stimulations
(time-dependent inhibition). In con- trol subjects, a pair of arginine ... Cited by 14 - Related articles - All 3 versions
