- ►diabetesjournals.org JC Henquin, N Ishiyama, M Nenquin, MA … - Diabetes, 2002 - Am Diabetes Assoc Rapid and sustained stimulation of β-cells with glucose induces biphasic
insulin secretion. The two phases appear to reflect a characteristic of
stimulus-secretion coupling in each β-cell rather than heterogeneity in ... Cited by 59 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org S Barg, L Eliasson, E Renström, P Rorsman - Diabetes, 2002 - Am Diabetes Assoc Capacitance measurements were applied to mouse pancreatic ß-cells to elucidate
the cellular mechanisms underlying biphasic insulin secretion. We report here
that only <50 of the ß-cell's >10,000 granules are immediately available ... Cited by 88 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org FC Jonkers, JC Henquin - Diabetes, 2001 - Am Diabetes Assoc The proportion of isolated single β-cells developing a metabolic, biosynthetic,
or secretory response increases with glucose concentration (recruitment). It is
unclear whether recruitment persists in situ when β-cells are coupled. We ... Cited by 39 - Related articles - BL Direct - All 7 versions
[CITATION] Molecular and cellular biology of the beta cell
MJ Garcia-Barrado, MA Ravier, JF Rolland, P … - Endocrinology, 2001 - Endocrine Soc Proteins with a short half-life are potential sites of pancreatic ß cell
dysfunction under pathophysiological conditions. In this study, mouse islets
were used to establish which step in the regulation of insulin secretion is ... Cited by 22 - Related articles - BL Direct - All 4 versions
- ►physiology.org SG Straub, GWG Sharp - American Journal of Physiology- Cell Physiology, 2004 - Am Physiological Soc The biphasic secretory response of pancreatic -cells to abrupt and sustained
exposure to glucose is well documented. Some of the ATP-sensitive K + (K ATP )
channel-dependent mechanisms underlying the first phase of insulin release ... Cited by 22 - Related articles - All 3 versions
- ►diabetesjournals.org R Nesher, E Cerasi - Diabetes, 2002 - Am Diabetes Assoc The cellular and molecular mechanisms of insulin secretion are being intensively
investigated, yet most researchers are seemingly unaware of the complexity of
the dynamic regulation of the secretion. In this article, we summarize ... Cited by 55 - Related articles - BL Direct - All 5 versions
- ►jbc.org S Dalle, P Smith, P Blache, D Le-Nguyen, L Le … - Journal of Biological Chemistry, 1999 - ASBMB Using the MIN6 B-cell line, we investigated the hypothesis that miniglucagon,
the C-terminal (19-29) fragment processed from glucagon and present in
pancreatic A cells, modulates insulin release, and we analyzed its cellular ... Cited by 29 - Related articles - BL Direct - All 5 versions
R NESHER, E CERASI - Endocrinology, 1987 - Endocrine Soc The dynamics of insulin release were investigated in vitro in order to determine
the regulatory processes governing its biphasic shape. When subjected to a
square wave glucose stimulation, the isolated perfused rat pancreas ... Cited by 46 - Related articles - All 4 versions
TK Bratanova-Tochkova, H Cheng, S Daniel, … - Diabetes, 2002 - Am Diabetes Assoc The insulin secretory response by pancreatic ß-cells to an acute "square wave"
stimulation by glucose is characterized by a first phase that occurs promptly
after exposure to glucose, followed by a decrease to a nadir, and a ... Cited by 108 - Related articles - BL Direct - All 6 versions
