TK Bratanova-Tochkova, H Cheng, S Daniel, … - Diabetes, 2002 - Am Diabetes Assoc The insulin secretory response by pancreatic ß-cells to an acute "square wave"
stimulation by glucose is characterized by a first phase that occurs promptly
after exposure to glucose, followed by a decrease to a nadir, and a ... Cited by 108 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org S Barg, L Eliasson, E Renström, P Rorsman - Diabetes, 2002 - Am Diabetes Assoc Capacitance measurements were applied to mouse pancreatic ß-cells to elucidate
the cellular mechanisms underlying biphasic insulin secretion. We report here
that only <50 of the ß-cell's >10,000 granules are immediately available ... Cited by 87 - Related articles - BL Direct - All 4 versions
SG Straub, GWG Sharp - Diabetes/Metabolism Reviews - interscience.wiley.com Glucose-stimulated biphasic insulin secretion involves at least two signaling
pathways, the KATP channel-dependent and KATP channel-independent pathways,
respectively. In the former, enhanced glucose metabolism increases the ... Cited by 156 - Related articles - BL Direct - All 3 versions
CS Olofsson, SO Göpel, S Barg, J … - Pflügers Archiv European Journal of Physiology, 2002 - Springer Abstract A readily releasable pool (RRP) of granules has been proposed to
underlie the first phase of insulin secretion. In the present study we combined
electron mi- croscopy, insulin secretion measurements and recordings of ... Cited by 93 - Related articles - BL Direct - All 4 versions
P Rorsman, E Renström - Diabetologia, 2003 - Springer Glucose-induced insulin secretion in response to a step increase in blood
glucose concentrations follows a bi- phasic time course consisting of a rapid
and transient first phase followed by a slowly developing and sus- tained ... Cited by 204 - Related articles - BL Direct - All 3 versions
P Rorsman, L Eliasson, E Renström, J … - News in physiological sciences: an international …, 2000 - ncbi.nlm.nih.gov Glucose-stimulated insulin secretion consists of a transient first phase
followed by a sustained second phase. Diabetes (type II) is associated with
abnormalities in this release pattern. Here we review the evidence that ... Cited by 126 - Related articles - BL Direct - All 9 versions
- ►diabetesjournals.org JC Henquin, N Ishiyama, M Nenquin, MA … - Diabetes, 2002 - Am Diabetes Assoc Rapid and sustained stimulation of β-cells with glucose induces biphasic
insulin secretion. The two phases appear to reflect a characteristic of
stimulus-secretion coupling in each β-cell rather than heterogeneity in ... Cited by 59 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] S Daniel, M Noda, SG Straub, GW Sharp - Diabetes, 1999 - Am Diabetes Assoc The mechanisms underlying the first phase of glucose- stimulated insulin
release, the deterioration of which marks the early stages of both type 1 and
type 2 dia- betes, are essentially unknown. Among many hypothe- ses, one ... Cited by 115 - Related articles - BL Direct - All 5 versions
- ►nih.gov [PDF] S Barg, X Ma, L Eliasson, J Galvanovskis, SO … - Biophysical Journal, 2001 - Elsevier The association of L-type Ca 2+ channels to the secretory granules and its
functional significance to secretion was investigated in mouse pancreatic B
cells. Nonstationary fluctuation analysis showed that the B cell is ... Cited by 116 - Related articles - BL Direct - All 5 versions
- ►nih.gov [PDF] L Eliasson, E Renström, WG Ding, P Proks, … - The Journal of Physiology, 1997 - pubmedcentral.nih.gov Rapid ATP-dependent priming of secretory granules precedes ... Ca2+-induced
exocytosis in mouse pancreatic B-cells ... Lena Eliasson *, Erik Renstrom t,
Wei-Guang Ding t, Peter Prokst and Patrik Rorsman t Cited by 135 - Related articles - BL Direct - All 9 versions
