T Aizawa, Y Sato, M Komatsu - Diabetes, 2002 - Am Diabetes Assoc Glucose induces biphasic insulin secretion by the islet β-cell. Based on recent
knowledge on glucose signaling in the β-cell, the underlying mechanisms for
this biphasicity could be envisaged as follows. Glucose-induced elevation ... Cited by 19 - Related articles - BL Direct - All 5 versions
- ►googlepages.com [PDF] Y Guiot, M Stevens, I Marhfour, P Stiernet, M … - Diabetologia, 2007 - Springer Abstract Aims/hypothesis Sulfonylurea receptor 1 (SUR1) is the regulatory
subunit of ATP-sensitive K channels in beta cells. Morphological methods
(immunohistochemistry and sulfonylurea binding) were used to establish the ... Cited by 4 - Related articles - BL Direct - All 5 versions
- ►jbc.org M Nenquin, A Szollosi, L Aguilar-Bryan, J … - Journal of Biological Chemistry, 2004 - ASBMB In normal -cells glucose induces insulin secretion by activating both a
triggering pathway (closure of K ATP channels, depolarization, and rise in
cytosolic [Ca 2+ ] i ) and an amplifying pathway (augmentation of Ca 2+ ... Cited by 44 - Related articles - BL Direct - All 5 versions
M Düfer, D Haspel, P Krippeit-Drews, L … - Diabetologia, 2004 - Springer Aims/hypothesis. SUR1(ABCC8) −/− mice lacking func- tional KATP channels are
an appropriate model to test the significance of KATP channels in beta-cell
function. We examined how this gene deletion interferes with ... Cited by 26 - Related articles - BL Direct - All 4 versions
- ►endojournals.org S Yamada, M Komatsu, Y Sato, K Yamauchi, T … - Endocrinology, 2003 - Endocrine Soc Protein acylation in glucose stimulation of insulin secretion in the ß-cells
has been implicated. Accordingly, we attempted to identify the target(s) of
acylation in the pancreatic islets. Rat pancreatic islets were labeled with ... Cited by 10 - Related articles - BL Direct - All 4 versions
- ►ebmonline.org I Niki, T Niwa, W Yu, D Budzko, T Miki, T … - Experimental Biology and Medicine, 2003 - SEBM This study investigated mechanisms by which glucose increases readily releasable
secretory granules via acting on preexocytotic steps, ie, intracellular granule
movement and granule access to the plasma membrane using a pancreatic ... Cited by 12 - Related articles - BL Direct - All 3 versions
- ►physiology.org NM Doliba, W Qin, MZ Vatamaniuk, CW … - American Journal of Physiology- Endocrinology And …, 2006 - Am Physiological Soc Neural and endocrine factors (ie, Ach and GLP-1) restore defective
glucose-stimulated insulin release in pancreatic islets lacking sulfonylurea
type 1 receptors (SUR1 –/– ) (Doliba NM, Qin W, Vatamaniuk MZ, Li C, ... Cited by 12 - Related articles - BL Direct - All 4 versions
LI Nicholls, EK Ainscow, GA Rutter - Biochemical and Biophysical Research …, 2002 - Elsevier Glucose-stimulated increases in mitochondrial metabolism are generally thought
to be important for the activation of insulin secretion. Pyruvate dehydrogenase
(PDH) is a key regulatory enzyme, believed to govern the rate of pyruvate ... Cited by 14 - Related articles - BL Direct - All 5 versions
P Gilon, MA Ravier, JC Jonas, JC Henquin - Diabetes, 2002 - Am Diabetes Assoc The mechanisms driving the pulsatility of insulin secretion in vivo and in vitro
are still unclear. Because glucose metabolism and changes in cytosolic free Ca
2+ ([Ca 2+ ] c ) in β-cells play a key role in the control of insulin ... Cited by 50 - Related articles - BL Direct - All 5 versions
CB Newgard, HE Hohmeier, D Lu, MV Jensen, … - Cell biochemistry and biophysics, 2004 - Springer Type 1 and type 2 diabetes are both diseases of insulin insufficiency, although
they develop by distinct pathways. The recent surge in the incidence of type 2
diabetes and the chronic ail- ments confronted by patients with either form ... Cited by 4 - Related articles - BL Direct - All 5 versions
