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Scholar Results 1 - 10 of about 101 related to Maechler: Implication of glutamate in the kinetics of insulin secretion in rat and mouse.... (0.13 sec) 

Implication of glutamate in the kinetics of insulin secretion in rat and mouse …

- diabetesjournals.org
P Maechler, A Gjinovci, CB Wollheim - Diabetes, 2002 - Am Diabetes Assoc
It is intriguing that the kinetics of glucose-stimulated insulin secretion from the in situ perfused
pancreas differ between the rat and the mouse. Here we confirm that insulin release in the rat
is clearly biphasic, whereas in the mouse glucose essentially elicits a transient ...
Cited by 24 - Related articles - BL Direct - All 6 versions

Glucose metabolism and glutamate analog acutely alkalinize pH of insulin …

- physiology.org
K Eto, T Yamashita, K Hirose, Y … - American Journal of …, 2003 - Am Physiological Soc
We studied acute changes of secretory vesicle pH in pancreatic -cells with a fluorescent pH
indicator, lysosensor green DND-189. Fluorescence was decreased by 0.66 ± 0.10% at 149
± 16 s with 22.2 mM glucose stimulation, indicating that vesicular pH was alkalinized by ...
Cited by 16 - Related articles - BL Direct - All 4 versions

[CITATION] Glutamate acts as a mitochondrially derived messenger in glucose-induced insulin …


P Maechler, CB Wollheim - Nature, 1999
Cited by 8 - Related articles

Insulinotropic action of glutamic acid dimethyl ester


A Sener, I Conget, J Rasschaert, V … - American Journal of …, 1994 - Am Physiological Soc
Insulinotropic action of glutamic acid dimethyl ester ... ABDULLAH SENER, IGNACIO
CONGET, JOANNE RASSCHAERT, VMANE LECLERCQ-MEYER, MARIA L.
VILLANUEVA-PENACARRILLO, ISABEL VALVERDE, AND WILLY J. MALAISSE ...
Cited by 25 - Related articles - BL Direct - All 4 versions

Characterization of vesicular glutamate transporter in pancreatic alpha-and beta- …

- physiology.org
L Bai, X Zhang, FK Ghishan - American Journal of Physiology- …, 2003 - Am Physiological Soc
Glutamate has been suggested to play an important role in the release of insulin and glucagon
from pancreatic cells via exocytosis. Vesicular glutamate transporter is a rate-limiting step for
glutamate release and is involved in the glutamate-evoked exocytosis. Two vesicular ...
Cited by 28 - Related articles - BL Direct - All 4 versions

Regulatory effects of 5′-deoxypyridoxal on glutamate dehydrogenase activity and …


SJ Yang, JW Huh, MJ Kim, WJ Lee, TU Kim, SY Choi, … - Biochimie, 2003 - Elsevier
It has been known that glutamate, generated by glutamate dehydrogenase (GDH), acts as an
intracellular messenger in insulin exocytosis in pancreatic β cells. Here we demonstrate the correlation
of GDH activity and insulin release in rat pancreatic islets perfused with ...
Cited by 14 - Related articles - All 5 versions

Modulation of glutamate generation in mitochondria affects hormone secretion in …


P Maechler, PA Antinozzi, CB Wollheim - IUBMB life, 2000 - interscience.wiley.com
It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ...
Cited by 24 - Related articles - BL Direct - All 5 versions

Regulation of the glutamate dehydrogenase activity in rat islets of Langerhans and …


J Bryła, M Michalik, J Nelson, M Erecińska - Metabolism: clinical and …, 1994 - ncbi.nlm.nih.gov
1: Metabolism. 1994 Sep;43(9):1187-95. Regulation of the glutamate dehydrogenase
activity in rat islets of Langerhans and its consequence on insulin release. Bryła J,
Michalik M, Nelson J, Erecińska M. Department of Pharmacology ...
Cited by 27 - Related articles - BL Direct - All 3 versions

[CITATION] Martin-Del-Rio, R. and Maechler, P.(2004) Insulin secretion profiles are modified …


S Carobbio, H Ishihara, S Fernandez-Pascual, C … - Diabetologia
Cited by 7 - Related articles

GAD65-mediated glutamate decarboxylation reduces glucose-stimulated insulin …


B Rubi, H Ishihara, FG Hegardt, CB Wollheim, P … - Journal of Biological …, 2001 - ASBMB
Mitochondrial metabolism plays a pivotal role in the pancreatic beta cell by generating signals
that couple glucose sensing to insulin secretion. We have demonstrated previously that mitochondrially
derived glutamate participates directly in the stimulation of insulin exocytosis. The aim of ...
Cited by 50 - Related articles - BL Direct - All 6 versions


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