D Melloul, S Marshak, E Cerasi - Diabetes, 2002 - Am Diabetes Assoc The homeodomain-containing transcription factor pancreatic duodenal homeobox 1
(PDX-1) plays a key role in pancreas development and in β-cell function.
Upstream sequences of the gene up to about −6 kb show islet-specific ... Cited by 27 - Related articles - BL Direct - All 3 versions
D Melloul, N Kaiser, E Cerasi - Current Opinion in Endocrinology, Diabetes and …, 2000 - journals.lww.com Deficient insulin secretion and relative hyperproinsulinemia are characteristic
of non-insulin-dependent diabetes. Culture of human islets at high glucose
concentrations generates β-cell dysfunctions that mimic those observed in ... Cited by 4 - Related articles - BL Direct
G Leibowttz, D Melloul, M Yuli, DJ Gross, A … - DIABETES-NEW YORK-, 2001 - Am Diabetes Assoc T ype 2 diabetes is associated with obesity, impaired insulin action, and
defective insulin secretion (1). Although the relative contributions of insulin
resistance and insulin deficiency to the pathogen- esis of type 2 diabetes ... Cited by 12 - Related articles - BL Direct - All 5 versions
- ►jbc.org SE Samaras, L Zhao, A Means, E Henderson, … - Journal of Biological Chemistry, 2003 - ASBMB Pancreatic duodenal homeobox factor-1, PDX-1, is required for pancreas
development, islet cell differentiation, and the maintenance of cell function.
Selective expression in the pancreas appears to be principally regulated by ... Cited by 42 - Related articles - BL Direct - All 4 versions
H Watanabe, H Saito, H Nishimura, J Ueda, … - Pancreas, 2008 - pubmedcentral.nih.gov The role of PI3K in PDX-1 expression and duct cell differentiation with
pancreatic regeneration in mice after partial pancreatectomy (Px) was examined
using either wortmannin, a pharmacologic PI3K inhibitor, or siRNA directed ... Cited by 2 - Related articles - BL Direct - All 4 versions
E Ben-Shushan, S Marshak, M Shoshkes, E … - Journal of Biological Chemistry, 2001 - ASBMB The PDX-1 transcription factor plays a key role in pancreas development.
Although expressed in all cells at the early stages, in the adult it is mainly
restricted to the -cell. To characterize the regulatory elements and ... Cited by 65 - Related articles - BL Direct - All 4 versions
E Ben-Shushan, S Marshak, M Shoshkes, E … - J Biol Chem, 2001 - ASBMB The PDX-1 transcription factor plays a key role in pancreas development.
Although expressed in all cells at the early stages, in the adult it is mainly
restricted to the -cell. To characterize the regulatory elements and ... Cited by 8 - Related articles
BS Etti, S Marshak, M Shoshkes, E Cerasi, D … - Journal of Biological Chemistry - ASBMB Page 1. A Pancreatic ك-Cell-Specific Enhancer in the Human Pdx-1 Gene is
Regulated by HNF-3ك, HNF-1α and SPs Transcription Factors. ... Related articles
I Artner, R Stein - Journal of Biological Chemistry - ASBMB PDX-1 regulates transcription of genes involved in islet b cell function and
pancreas development. Islet-specific expression is controlled by 5-flanking
sequences from base pair (bp) -2917 to -1918 in transgenic experiments, ... Related articles
M Gannon, LW Gamer, CVE Wright - Developmental Biology, 2001 - Elsevier 14. K. Gerrish, S. Samaras, MA Cissell, CVE Wright and R. Stein, Regulation of
PDX1 gene expression. In: MA Hussein, CP Miller and JF Habener, Editors, The
Molecular Basis of Pancreatic Development and Function, Kluwer Academic, ... Cited by 56 - Related articles - BL Direct - All 4 versions
