- ►diabetesjournals.org F Schuit, D Flamez, A De Vos, D Pipeleers - Diabetes, 2002 - Am Diabetes Assoc The mammalian β-cell has particular properties that synthesize, store, and secrete insulin in
quantities that are matched to the physiological demands of the organism. To achieve this
task, β-cells are regulated both acutely and chronically by the extracellular glucose ... Cited by 55 - Related articles - BL Direct - All 5 versions
- ►nih.gov GC Webb, MS Akbar, C Zhao, DF … - Proceedings of the …, 2000 - National Acad Sciences Pancreatic β cells respond to changes in blood glucose by secreting insulin and increasing insulin
synthesis. To identify genes used in these responses, we have carried out expression profiling
of β cells exposed to high (25 mM) or low (5.5 mM) glucose by using oligonucleotide ... Cited by 117 - Related articles - BL Direct - All 11 versions
D Flamez, V Berger, M Kruhøffer, T Orntoft, D Pipeleers, … - Diabetes, 2002 - Am Diabetes Assoc The molecular mechanisms mediating acute regulation of insulin release by glucose are partially
known. The process involves at least two pathways that can be discriminated on basis of their
(in)dependence of closure of ATP-sensitive potassium (K + ATP ) channels. The ... Cited by 71 - Related articles - BL Direct - All 5 versions
SA Hinke, K Hellemans, FC Schuit - The Journal of physiology, 2004 - Physiological Soc It is well established that the acute rise in plasma glucose and in the incretin hormones
glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (7–36) amide
(GLP-1), as occurs during a meal, is of pivotal importance in regulating the ... Cited by 26 - Related articles - All 9 versions
Z Ling, R Kiekens, T Mahler, FC Schuit, M Pipeleers- … - Diabetes, 1996 - Am Diabetes Assoc This study examines the effects of chronically elevated glucose levels on the survival and function
of purified rat beta-cells. Prolonged exposure (9 days) of beta-cell aggregates to 20 mmol/l glucose
did not lead to cell losses, but reduced the amount of insulin secreted in response to ... Cited by 81 - Related articles - BL Direct - All 5 versions
- ►physiology.org MZ Khaldi, Y Guiot, P Gilon, JC Henquin, … - American Journal of …, 2004 - Am Physiological Soc Chronic hyperglycemia has been shown to induce either a lack of response or an increased
sensitivity to glucose in pancreatic -cells. We reinvestigated this controversial issue in a single
experimental model by culturing rat islets for 1 wk in 10 or 30 mmol/l glucose (G10, ... Cited by 29 - Related articles - BL Direct - All 5 versions
- ►jbc.org JC Jonas, DR Laybutt, GM Steil, N Trivedi, JG … - Journal of Biological …, 2001 - ASBMB Glucose-induced insulin secretion from hyperglycemic 90% pancreatectomized rats is markedly
impaired, possibly because of loss of cell differentiation. Association of these changes with cell
hypertrophy, increased mRNA levels of the transcription factor c-Myc, and their complete ... Cited by 64 - Related articles - BL Direct - All 5 versions
- ►jbc.org DR Laybutt, A Sharma, DC Sgroi, J Gaudet, S … - Journal of Biological …, 2002 - ASBMB In models of type 2 diabetes the expression of -cell genes is altered, but these changes have
not fully explained the impairment in -cell function. We hypothesized that changes in -cell phenotype
and global alterations in both carbohydrate and lipid pathways are likely to contribute to ... Cited by 98 - Related articles - BL Direct - All 5 versions
- ►endojournals.org [PDF] V Lilla, G Webb, K Rickenbach, A Maturana, DF Steiner … - Endocrinology, 2003 - Endocrine Soc To identify genes involved in regulated insulin secretion, we have established and characterized
two sublines derived from the mouse pancreatic ß-cell line MIN6, designated B1 and C3. They
have a similar insulin content, but differ in their secre- tory properties. B1 responded to ... Cited by 41 - Related articles - BL Direct - All 4 versions
[CITATION] In't Veld PA, Pipeleers DG (1988) Glucose stimulates proinsulin biosynthesis by a …
