C Schwanstecher, M Schwanstecher - Diabetes, 2002 - Am Diabetes Assoc Type 2 diabetes is generally perceived as a polygenic disorder, with disease
development being influenced by both hereditary and environmental factors.
However, despite intensive investigations, little progress has been made in ... Cited by 39 - Related articles - BL Direct - All 3 versions
C Schwanstecher, B Neugebauer, M Schulz, … - Diabetes, 2002 - Am Diabetes Assoc E23K, a common polymorphism in the pore-forming subunit K IR 6.2 of pancreatic
β-cell ATP-sensitive K + (K ATP ) channels, is functionally relevant and thus
might play a major role in the pathophysiology of common type 2 diabetes. ... Cited by 32 - Related articles - BL Direct - All 3 versions
H Sakura, N Wat, V Horton, H Millns, RC … - Diabetologia, 1996 - Springer Summary The ATP-sensitive K-channel plays a cen- tral role in insulin release
from pancreatic beta cells. This channel consists of two subunits: a sulphonyl-
urea receptor, SUR1, and an inwardly rectifying K- channel subunit, Kir6.2. ... Cited by 71 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org C Schwanstecher, U Meyer, M … - Diabetes, 2002 - Am Diabetes Assoc E23K, a common single nucleotide polymorphism in K IR 6.2, the pore-forming
subunit of pancreatic β-cell ATP-sensitive K + channels, significantly enhanced
open probability of these channels, thus reducing their sensitivity toward ... Cited by 124 - Related articles - BL Direct - All 18 versions
L Love-Gregory, J Wasson, J Lin, G Skolnick, … - Diabetologia, 2003 - Springer 2. Wren A, Seal L, Cohen M et al. (2001) Ghrelin enhances appetite and increases
food intake in humans. J Clin Endo- crinol Metab 86: 5992–5995 3. Tschop M,
Weyer C, Tataranni P, Devanarayan V, Ravussin E, Heiman M (2001) ... Cited by 70 - Related articles - BL Direct - All 3 versions
[CITATION] Sequence variants in the pancreatic islet b-cell inwardly rectifying K+ channel Kir6. 2 (Bir) …
H Inoue, J Ferrer, M Warren-Perry, Y Zhang, … - Diabetes-American Diabetes Association, 1997 - [New York, American Diabetes Association] Cited by 28 - Related articles - BL Direct
H Inoue, J Ferrer, M Warren-Perry, Y Zhang, … - Diabetes, 1997 - Am Diabetes Assoc Signals derived from the metabolism of glucose in pancreatic beta-cells lead to
insulin secretion via the closure of ATP-sensitive K+ channels (KATP). The
cloning of the gene encoding the beta-cell inward rectifier Kir6.2 (Bir), a ... Cited by 60 - Related articles - All 4 versions
EMD Nielsen, L Hansen, B Carstensen, SM … - Diabetes, 2003 - Am Diabetes Assoc The E23K polymorphism of the pancreatic β-cell ATP-sensitive K + (K ATP )
channel subunit Kir6.2 (KCNJ11) is associated with type 2 diabetes in whites,
and a recent in vitro study of the E23K variant suggests that the ... Cited by 146 - Related articles - BL Direct - All 5 versions
AL Gloyn, Y Hashim, SJH Ashcroft, R Ashfield, … - Diabetic Medicine, 2001 - interscience.wiley.com Aims The beta-cell ATP-sensitive potassium channel consists of two subunits,
SUR1 and Kir6.2. Population association studies have shown that three variants
in SUR1 and one in Kir6.2 are associated with Type 2 diabetes. These ... Cited by 76 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org LM t Hart, TW van Haeften, JM Dekker, M Bot … - Diabetes, 2002 - Am Diabetes Assoc An association between type 2 diabetes and genetic variation in the KIR6.2 gene
has been reported in several populations. Based on in vitro studies with cell
lines expressing the Glu 23 Lys (E23K) mutation, it was recently suggested ... Cited by 19 - Related articles - BL Direct - All 6 versions
