C Schwanstecher, B Neugebauer, M Schulz, … - Diabetes, 2002 - Am Diabetes Assoc E23K, a common polymorphism in the pore-forming subunit K IR 6.2 of pancreatic
β-cell ATP-sensitive K + (K ATP ) channels, is functionally relevant and thus
might play a major role in the pathophysiology of common type 2 diabetes. ... Cited by 32 - Related articles - BL Direct - All 3 versions
- ►hivinfosource.org [PDF] MJ Riedel, P Boora, D Steckley, G de Vries, … - Diabetes, 2003 - Am Diabetes Assoc The commonly occurring E23K and I337V Kir6.2 polymorphisms in the ATP-sensitive
potassium (K ATP ) channel are more frequent in Caucasian type 2 diabetic
populations. However, the underlying cellular mechanisms contributing to ... Cited by 51 - Related articles - BL Direct - All 25 versions
C Schwanstecher, M Schwanstecher - Diabetes, 2002 - Am Diabetes Assoc Type 2 diabetes is generally perceived as a polygenic disorder, with disease
development being influenced by both hereditary and environmental factors.
However, despite intensive investigations, little progress has been made in ... Cited by 39 - Related articles - BL Direct - All 3 versions
O Tschritter, M Stumvoll, F Machicao, M … - Diabetes, 2002 - Am Diabetes Assoc Genetic factors play an important role in the pathogenesis of type 2 diabetes.
The relevance to type 2 diabetes of the common polymorphism Glu23Lys in the
potassium inward rectifier 6.2 (KIR6.2) gene is still controversial. The ... Cited by 44 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org LM t Hart, TW van Haeften, JM Dekker, M Bot … - Diabetes, 2002 - Am Diabetes Assoc An association between type 2 diabetes and genetic variation in the KIR6.2 gene
has been reported in several populations. Based on in vitro studies with cell
lines expressing the Glu 23 Lys (E23K) mutation, it was recently suggested ... Cited by 19 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org C Schwanstecher, U Meyer, M … - Diabetes, 2002 - Am Diabetes Assoc E23K, a common single nucleotide polymorphism in K IR 6.2, the pore-forming
subunit of pancreatic β-cell ATP-sensitive K + channels, significantly enhanced
open probability of these channels, thus reducing their sensitivity toward ... Cited by 124 - Related articles - BL Direct - All 18 versions
H Sakura, N Wat, V Horton, H Millns, RC … - Diabetologia, 1996 - Springer Summary The ATP-sensitive K-channel plays a cen- tral role in insulin release
from pancreatic beta cells. This channel consists of two subunits: a sulphonyl-
urea receptor, SUR1, and an inwardly rectifying K- channel subunit, Kir6.2. ... Cited by 71 - Related articles - BL Direct - All 3 versions
L Love-Gregory, J Wasson, J Lin, G Skolnick, … - Diabetologia, 2003 - Springer 2. Wren A, Seal L, Cohen M et al. (2001) Ghrelin enhances appetite and increases
food intake in humans. J Clin Endo- crinol Metab 86: 5992–5995 3. Tschop M,
Weyer C, Tataranni P, Devanarayan V, Ravussin E, Heiman M (2001) ... Cited by 70 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org EL Edghill, AL Gloyn, KM Gillespie, AP … - Diabetes, 2004 - Am Diabetes Assoc We have recently shown that permanent neonatal diabetes can be caused by
activating mutations in KCNJ11 that encode the Kir6.2 subunit of the ß-cell
ATP-sensitive K + channel. Some of these patients were diagnosed after 3 ... Cited by 25 - Related articles - BL Direct - All 4 versions
- ►endojournals.org AL Gloyn, EA Cummings, EL Edghill, LW Harries … - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc Activating mutations in the KCNJ11 gene encoding for the Kir6.2 subunit of the
ß-cell ATP-sensitive potassium channel have recently been shown to be a common
cause of permanent neonatal diabetes. In 80% of probands, these are ... Cited by 42 - Related articles - BL Direct - All 7 versions
