- ►diabetesjournals.org P Proks, F Reimann, N Green, F Gribble, F … - Diabetes, 2002 - Am Diabetes Assoc Sulfonylureas are widely used to treat type 2 diabetes because they stimulate
insulin secretion from pancreatic ß-cells. They primarily act by binding to the
SUR subunit of the ATP-sensitive potassium (K ATP ) channel and inducing ... Cited by 116 - Related articles - BL Direct - All 3 versions
F Reimann, P Proks, FM Ashcroft - British Journal of Pharmacology, 2001 - pubmedcentral.nih.gov We have investigated the mechanism of action of the novel anti-diabetic agent
mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of
ATP-sensitive potassium (K ATP ) channel. These possess a common ... Cited by 37 - Related articles - BL Direct - All 3 versions
- ►nih.gov F Reimann, M Dabrowski, P Jones, FM Gribble … - The Journal of Physiology, 2003 - Physiological Soc Sulphonylureas stimulate insulin secretion by binding with high-affinity to the
sulphonylurea receptor (SUR) subunit of the ATP-sensitive potassium (K ATP )
channel and thereby closing the channel pore (formed by four Kir6.2 ... Cited by 21 - Related articles - BL Direct - All 7 versions
FM Gribble, FM Ashcroft - Diabetologia, 1999 - Springer Aims/hypothesis. To investigate the tissue specificity of gliclazide for cloned
beta-cell, cardiac and smooth muscle ATP-sensitive K-channels (K ATP channels).
These channels share a common pore-forming sub- unit, Kir6.2, which ... Cited by 69 - Related articles - BL Direct - All 3 versions
FM Gribble, F Reimann - Journal of diabetes and its complications, 2003 - Elsevier The sulphonylurea receptor (SUR) subunits of K ATP channels are the targets for
several classes of therapeutic drugs. Sulphonylureas close K ATP channels in
pancreatic β-cells and are used to stimulate insulin release in type 2 ... Cited by 25 - Related articles - All 7 versions
- ►aspetjournals.org A Hambrock, C Loffler-Walz, U Russ, U Lange … - Molecular Pharmacology, 2001 - ASPET ATP-dependent K + channels are composed of pore-forming subunits of the Kir6.x
family and of sulfonylurea receptors (SURs). SUR1, expressed in pancreatic
-cells, has a higher affinity for sulfonylureas, such as glibenclamide, ... Cited by 45 - Related articles - BL Direct - All 2 versions
AMK Hansen, IT Christensen, JB Hansen, RD … - Diabetes, 2002 - Am Diabetes Assoc Repaglinide and nateglinide represent a new class of insulin secretagogues,
structurally unrelated to sulphonylureas, that were developed for the treatment
of type 2 diabetes. The inhibitory effect of these drugs was investigated ... Cited by 49 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org [PDF] FM Gribble, SJ Tucker, S Seino, FM Ashcroft - Diabetes, 1998 - Am Diabetes Assoc Sulfonylureas stimulate insulin secretion from pancre- atic -cells by closing
ATP-sensitive K+ ( KAT P). The - cell and cardiac muscle KAT P channels have
recently been cloned and shown to possess a common pore-forming subunit ... Cited by 175 - Related articles - BL Direct - All 4 versions
J Bryan, A Crane, WH Vila-Carriles, AP … - Current pharmaceutical design, 2005 - ingentaconnect.com Abstract: ATP-sensitive K + channels, termed K ATP channels, provide a link
between cellular metabolism and membrane electrical activity in a variety of
tissues. Channel isoforms have been identified and are targets for ... Cited by 38 - Related articles - BL Direct - All 4 versions
FM Gribble, F Reimann - Diabetologia, 2003 - Springer Hypoglycaemic agents such as sulphonylureas and the newer group of
“glinides” stimulate insulin secretion by closing ATP-sensitive potassium (K
ATP ) channels in pancreatic beta cells, but have varying cross-reac- ... Cited by 107 - Related articles - BL Direct - All 3 versions
