- ►diabetesjournals.org FM Matschinsky - Diabetes, 2002 - Am Diabetes Assoc Glucokinase (GK) serves as glucose sensor in pancreatic β-cells and in other
glucose sensor cells in the body. Biochemical genetic studies have characterized
many activating and inactivating GK mutants that have been discovered in ... Cited by 127 - Related articles - BL Direct - All 5 versions
- ►sciencesignaling.org [PDF] J Grimsby, R Sarabu, WL Corbett, NE Haynes, … - Science, 2003 - sciencemag.org Page 1. DOI: 10.1126/science.1084073 , 370 (2003); 301 Science et al. Joseph Grimsby,
in Diabetes Therapy Allosteric Activators of Glucokinase: Potential Role ... Cited by 187 - Related articles - All 12 versions
- ►diabetesjournals.org AL Gloyn, K Noordam, MAAP Willemsen, S … - Diabetes, 2003 - Am Diabetes Assoc Glucokinase (GCK) is a key regulatory enzyme in the pancreatic β-cell and
catalyzes the rate-limiting step for β-cell glucose metabolism. We report two
novel GCK mutations (T65I and W99R) that have arisen de novo in two ... Cited by 78 - Related articles - BL Direct - All 5 versions
- ►ox.ac.uk [PDF] KJ Brocklehurst, VA Payne, RA Davies, D … - Diabetes, 2004 - Am Diabetes Assoc Glucokinase (GK) has a major role in the control of blood glucose homeostasis
and is a strong potential target for the pharmacological treatment of type 2
diabetes. We report here the mechanism of action of two novel and potent ... Cited by 75 - Related articles - BL Direct - All 6 versions
HBT Christesen, BB Jacobsen, S Odili, C … - Diabetes, 2002 - Am Diabetes Assoc In this study, a second case of hyperinsulinemic hypoglycemia due to activation
of glucokinase is reported. The 14-year-old proband had a history of neonatal
hypoglycemia, treated with diazoxide. He was admitted with coma and ... Cited by 118 - Related articles - BL Direct - All 6 versions
Y Toyoda, S Yoshie, H Shironoguchi, I Miwa - Histochemistry and cell biology, 1999 - Springer Glucokinase (GK; ATP: D -hexose 6-phosphotransferase, EC 2.7.1.1), often called
hexokinase IV, catalyzes the phosphorylation of glucose. It is distinguished
from oth- er hexokinase isozymes (types I–III) by its low affinity for ... Cited by 25 - Related articles - BL Direct - All 3 versions
AL Gloyn - Human mutation, 2003 - interscience.wiley.com Glucokinase is a key regulatory enzyme in the pancreatic beta-cell. It plays a
crucial role in the regulation of insulin secretion and has been termed the
pancreatic beta-cell sensor. Given its central role in the regulation of ... Cited by 121 - Related articles - BL Direct - All 6 versions
- ►jbc.org MA Rizzo, MA Magnuson, PF Drain, DW … - Journal of Biological Chemistry, 2002 - ASBMB Glucokinase (GK) activity is essential for the physiological regulation of
insulin secretion by glucose. Because the enzyme exerts nearly total control
over glucose metabolism in the -cell, even small changes in GK activity ... Cited by 55 - Related articles - BL Direct - All 7 versions
M Tiedge, T Richter, S Lenzen - Archives of Biochemistry and Biophysics, 2000 - Elsevier The low-affinity glucose phosphorylating enzyme glucokinase has the function of
a physiological glucose sensor in pancreatic beta cells and in liver. In
contrast to the high-affinity hexokinase types I–III glucokinase shows ... Cited by 39 - Related articles - BL Direct - All 5 versions
M Tiedge, U Krug, S Lenzen - Biochimica et Biophysica Acta (BBA)/Protein …, 1997 - Elsevier -glucose with a preference for the α-anomer. There were no tissue specific
differences, no species differences in the electrophoretic mobility, and no
differences of the kinetic properties of these well conserved enzymes. The ... Cited by 34 - Related articles - BL Direct - All 5 versions
