M Prentki, E Joly, W El-Assaad, R Roduit - Diabetes, 2002 - Am Diabetes Assoc Type 2 diabetes is considered to be in most cases a polygenic disease with a
strong involvement of environmental factors, such as diet and exercise (1).
Glucose intolerance in association with hyperinsulinemia and insulin ... Cited by 177 - Related articles - BL Direct - All 3 versions
W El-Assaad, J Buteau, ML Peyot, C Nolan, R … - Endocrinology, 2003 - Endocrine Soc We have proposed the "glucolipotoxicity" hypothesis in which elevated free fatty
acids (FFAs) together with hyperglycemia are synergistic in causing islet
ß-cell damage because high glucose inhibits fat oxidation and consequently ... Cited by 173 - Related articles - BL Direct - All 5 versions
- ►endojournals.org V Poitout, RP Robertson - Endocrinology, 2002 - Endocrine Soc Chronic hyperglycemia and hyperlipidemia can exert deleterious effects on
ß-cell function, respectively referred to as glucotoxicity and lipotoxicity.
Over time, both contribute to the progressive deterioration of glucose ... Cited by 328 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org R Roduit, C Nolan, C Alarcon, P Moore, A … - Diabetes, 2004 - Am Diabetes Assoc The malonyl-CoA/long-chain acyl-CoA (LC-CoA) model of glucose-induced insulin
secretion (GIIS) predicts that malonyl-CoA derived from glucose metabolism
inhibits fatty acid oxidation, thereby increasing the availability of ... Cited by 88 - Related articles - BL Direct - All 7 versions
R Roduit, J Morin, F Masse, L Segall, E … - Journal of Biological Chemistry, 2000 - ASBMB To better understand the action of glucose on fatty acid metabolism in the -cell
and the link between chronically elevated glucose or fatty acids and -cell
decompensation in adipogenic diabetes, we investigated whether glucose ... Cited by 125 - Related articles - BL Direct - All 4 versions
- ►endojournals.org V Poitout, RP Robertson - Endocrine reviews, 2008 - Endocrine Soc Glucotoxicity, lipotoxicity, and glucolipotoxicity are secondary phenomena that
are proposed to play a role in all forms of type 2 diabetes. The underlying
concept is that once the primary pathogenesis of diabetes is established, ... Cited by 69 - Related articles - BL Direct - All 7 versions
- ►biologists.org H Wang, G Kouri, CB Wollheim - Journal of cell science, 2005 - jcs.biologists.org The reduction in insulin secretory capacity and ß-cell mass observed in type 2
diabetes is thought to be caused by glucolipotoxicity secondary to hyperglycemia
and hyperlipidemia. Our aim in this study was to elucidate the underlying ... Cited by 102 - Related articles - BL Direct - All 7 versions
- ►jbc.org S Gremlich, C Bonny, G Waeber, B Thorens - Journal of Biological Chemistry, 1997 - ASBMB IDX-1 (islet/duodenum homeobox-1) is a transcription factor expressed in the
duodenum and pancreatic beta and delta cells. It is required for embryonic
development of the pancreas and transactivates the Glut2, glucokinase, ... Cited by 167 - Related articles - BL Direct - All 5 versions
H Wang, P Maechler, PA Antinozzi, L Herrero … - Journal of Biological Chemistry, 2003 - ASBMB Accumulation of lipids in non-adipose tissues is often associated with Type 2
diabetes and its complications. Elevated expression of the lipogenic
transcription factor, sterol regulatory element binding protein-1c ... Cited by 70 - Related articles - BL Direct - All 5 versions
