- ►diabetesjournals.org K Eto, T Yamashita, J Matsui, Y Terauchi, M Noda, T … - Diabetes, 2002 - Am Diabetes Assoc Triacylglyceride (TG) accumulation in pancreatic ß-cells is associated with impaired insulin
secretion, which is called lipotoxicity. To gain a better understanding of the pathophysiology
of lipotoxicity, we generated three models of dysregulated fatty acid metabolism in ß-cells. ... Cited by 38 - Related articles - BL Direct - All 3 versions
- ►physiology.org I Leclerc, WW Woltersdorf, G da Silva … - American Journal of …, 2004 - Am Physiological Soc Metformin, a drug widely used in the treatment of type 2 diabetes, has recently been shown to
act on skeletal muscle and liver in part through the activation of AMP-activated protein kinase
(AMPK). Whether metformin or the satiety factor leptin, which also stimulates AMPK in ... Cited by 60 - Related articles - BL Direct - All 4 versions
C Andreolas, G da Silva Xavier, F Diraison, C Zhao, A … - Diabetes, 2002 - Am Diabetes Assoc Acetyl-CoA carboxylase I (ACCI) is a key lipogenic enzyme whose induction in islet β-cells may
contribute to glucolipotoxicity. Here, we provide evidence that enhanced insulin release plays
an important role in the activation of this gene by glucose. Glucose (30 vs. 3 mmol/l) ... Cited by 48 - Related articles - BL Direct - All 5 versions
F Diraison, E Motakis, LE Parton, GP Nason, I Leclerc, … - Diabetes, 2004 - Am Diabetes Assoc Accumulation of triglyceride in islets may contribute to the loss of glucose-stimulated insulin secretion
(GSIS) in some forms of type 2 diabetes (Diraison et al., Biochem J 373:769–778, 2004).
Here, we use adenoviral vectors and oligonucleotide microarrays to determine the effects ... Cited by 21 - Related articles - BL Direct - All 4 versions
G da Silva Xavier, I Leclerc, IP Salt, B … - Proceedings of the …, 2000 - National Acad Sciences Elevated glucose concentrations stimulate the transcription of the pre-proinsulin (PPI), L-type
pyruvate kinase (L-PK), and other genes in islet beta cells. In liver cells, pharmacological activation
by 5-amino-4-imidazolecarboxamide riboside (AICAR) of AMP-activated protein kinase ( ... Cited by 115 - Related articles - BL Direct - All 11 versions
- ►nih.gov [PDF] G da Silva Xavier, I Leclerc, A Varadi, T … - Biochemical …, 2003 - pubmedcentral.nih.gov AMP-activated protein kinase (AMPK) has recently been impli- cated in the control of preproinsulin
gene expression in pancreatic islet β-cells [da Silva Xavier, Leclerc, Salt, Doiron, Hardie, Kahn
and Rutter (2000) Proc. Natl. Acad. Sci. USA 97, 4023–4028]. Using pharmacological and ... Cited by 146 - Related articles - BL Direct - All 9 versions
T Tsuboi, G da Silva Xavier, I Leclerc, GA Rutter - Journal of Biological …, 2003 - ASBMB Changes in 5'-AMP-activated protein kinase (AMPK) activity have recently been implicated in
the control of insulin secretion by glucose (da Silva Xavier, G., Leclerc, I., Varadi, A., Tsuboi,
T., Moule, SK, and Rutter, GA (2003) Biochem. J. 371, 761–774). Here, we examine the ... Cited by 54 - Related articles - BL Direct - All 4 versions
S Zhang, KH Kim - Journal of Endocrinology, 1995 - Soc Endocrinology Malonyl-CoA, which is the unique product of acetyl-CoA carboxylase (ACC), may serve as a
metabolic coupler in glucose-stimulated insulin secretion by pancreatic β-cells. Therefore we
examined if and how ACC is affected by glucose in association with insulin secretion. ... Cited by 29 - Related articles - BL Direct - All 5 versions
- ►jlr.org K Tordjman, KN Standley, C Bernal-Mizrachi, TC … - The Journal of Lipid …, 2002 - ASBMB Fatty acids may promote type 2 diabetes by altering insulin secretion from pancreatic ß cells,
a process known as lipotoxicity. The underlying mechanisms are poorly understood. To test the
hypothesis that peroxisome proliferator-activated receptor (PPAR ) has a direct effect on ... Cited by 68 - Related articles - BL Direct - All 5 versions
- ►endocrinology-journals.org SK Richards, LE Parton, I Leclerc, GA Rutter, … - Journal of …, 2005 - Soc Endocrinology Treatment of type 1 diabetes by islet transplantation is currently limited by loss of functional
ß-cell mass after transplantation. We investigated here whether adenovirus-mediated changes
in AMP-activated protein kinase (AMPK) activity, previously shown to affect insulin ... Cited by 45 - Related articles - BL Direct - All 6 versions
