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Scholar Results 1 - 10 of about 101 related to MacDonald: Glucagon-like peptide-1 receptor activation antagonizes voltage-dependent repolarizing.... (0.13 sec) 

Glucagon-like peptide-1 receptor activation antagonizes voltage-dependent …


PE MacDonald, AMF Salapatek, MB Wheeler - Diabetes, 2002 - Am Diabetes Assoc
Glucagon-like peptide-1 (GLP-1) acts through its G-protein-coupled receptor to enhance
glucose-stimulated insulin secretion from pancreatic β-cells. This is believed to result from
modulation of at least two ion ...
Cited by 41 - Related articles - BL Direct - All 3 versions

[PDF] Glucagon-Like Peptide-1 Receptor Activation Antagonizes Voltage-Dependent …


APGDI Mechanism - Diabetes, 2002 - Am Diabetes Assoc
Glucagon-like peptide-1 (GLP-1) acts through its G- protein–coupled receptor to enhance
glucose-stimu- lated insulin secretion from pancreatic -cells. This is believed to result from
modulation of at least two ion ...
Related articles - All 2 versions

Glucagon-like peptide-1 inhibits pancreatic ATP-sensitive potassium channels via …

- endojournals.org
PE Light, M Fox, E Jocelyn, MJ Riedel, MB … - Molecular …, 2002 - Endocrine Soc
Glucagon-like peptide-1 (GLP-1) elicits a glucose-dependent insulin secretory effect via elevation
of cAMP and activation of protein kinase A (PKA). GLP-1-mediated closure of ATP-sensitive potassium
(K ATP ) channels is involved in ...
Cited by 41 - Related articles - BL Direct - All 2 versions

Demonstration of A-currents in pancreatic islet cells


PA Smith, K Bokvist, P Rorsman - Pflügers Archiv European Journal of …, 1989 - Springer
Abstract. Voltage-activated K + currents resistant to TEA but blockable by 4-AP were recorded from
mouse pancreatic islet cells. These currents first become observable during depolarizations to
voltages more positive than -40 mV, ...
Cited by 13 - Related articles - All 2 versions

Voltage-dependent K+ channels in pancreatic beta cells: role, regulation and …

- bcell.org [PDF] 
PE MacDonald, MB Wheeler - Diabetologia, 2003 - Springer
Insulin secretion from pancreatic islet beta cells is acutely regulated by a complex interplay of
metabolic and electrogenic events. The electrogenic mechanism regulating insulin secretion from beta
cells is com- monly referred to as ...
Cited by 74 - Related articles - BL Direct - All 4 versions

Temperature and redox state dependence of native Kv2. 1 currents in rat …


PE MacDonald, AMF Salapatek, MB … - The Journal of …, 2003 - Physiological Soc
In pancreatic β-cells, voltage-dependent K + (Kv) channels repolarise glucose-stimulated action
potentials. Kv channels are therefore negative regulators of Ca 2+ entry and insulin secretion. We
have recently demonstrated that ...
Cited by 18 - Related articles - BL Direct - All 6 versions

The expression and regulation of depolarization-activated K+ channels in the …


J Su, H Yu, N Lenka, J Hescheler, S Ullrich - Pflügers Archiv European Journal …, 2001 - Springer
Abstract The aim of the present study was to character- ize depolarization-activated outward
currents in insulin- secreting INS-1 cells and to investigate the role of K ... Keywords Action
potential regulation · Insulin ...
Cited by 31 - Related articles - BL Direct - All 3 versions

Members of the Kv1 and Kv2 voltage-dependent K+ channel families regulate …

- endojournals.org
PE MacDonald, XF Ha, J Wang, SR Smukler, AM … - Molecular …, 2001 - Endocrine Soc
In pancreatic ß-cells, voltage-dependent K + (Kv) channels are potential mediators of
repolarization, closure of Ca 2+ channels, and limitation of insulin secretion. The specific Kv
channels expressed in ß-cells and ...
Cited by 96 - Related articles - BL Direct - All 3 versions

Delayed rectifier K+ channel overexpression in transgenic islets and beta-cells …

- jbc.org [PDF] 
LH Philipson, MP Rosenberg, A Kuznetsov, ME … - Journal of Biological …, 1994 - ASBMB
(Received for publication, August 25, 1994, and in revised form, September 14, 1994) Louis €I.
PhilipsonSS, Michael P. Rosenbergl, Andrey KuznetsovS, Mary E. Lancastefl, Jennings F. Worley 1111,
Michael W. met, and Iain D. Dukes11 ...
Cited by 36 - Related articles - BL Direct - All 5 versions

The role of plasma membrane K+ and Ca2+ permeabilities for glucose induction of …


M Eberhardson, A Tengholm, E Grapengiesser - BBA-Biomembranes, 1996 - Elsevier
In individual pancreatic β-cells the rise of the cytoplasmic Ca 2+ concentration ([Ca 2+ ] i ),
induced by 11 mM glucose, is manifested either as oscillations (0.2–0.5 min −1 ) or as a
sustained elevation. The ...
Cited by 14 - Related articles - All 4 versions


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