- ►diabetesjournals.org S Efendic, AM Efanov, PO Berggren, SV Zaitsev - Diabetes, 2002 - Am Diabetes Assoc The imidazoline RX871024 increased basal- and glucose-stimulated insulin release in vitro
and in vivo. The compound inhibited activity of ATP-sensitive K + channels as well as
voltage-gated K + channels, which led to membrane depolarization, an increase in the ... Cited by 26 - Related articles - BL Direct - All 4 versions
AM Efanov, SV Zaitsev, HJ Mest, A Raap, IB Appelskog … - Diabetes, 2001 - Am Diabetes Assoc The insulinotropic activity of the novel imidazoline compound BL11282 was investigated. Intravenous
administration of BL11282 (0.3 mg · kg –1 · min –1 ) to anesthetized rats did not change blood
glucose and insulin levels under basal conditions, but produced a higher increase in ... Cited by 41 - Related articles - BL Direct - All 6 versions
SLF Chan, M Mourtada, NG Morgan - Diabetes, 2001 - Am Diabetes Assoc Efaroxan, like several other imidazoline reagents, elicits a glucose-dependent increase in insulin
secretion from pancreatic β-cells. This response has been attributed to efaroxan-mediated blockade
of K ATP channels, with the subsequent gating of voltage-sensitive calcium channels. ... Cited by 31 - Related articles - BL Direct - All 7 versions
- ►physiology.org AM Efanov, IB Appelskog, SM Abdel- … - American Journal of …, 2002 - Am Physiological Soc The insulinotropic activity of the imidazoline derivative RX871024 was compared in pancreatic
islets from nondiabetic Wistar rats and spontaneously diabetic Goto-Kakizaki (GK) rats. RX871024
significantly stimulated insulin secretion in islets from both animal groups. The ... Cited by 13 - Related articles - BL Direct - All 4 versions
SV Zaitsev, AM Efanov, A Raap, IB Efanova, J … - Annals of the New York …, 1999 - ncbi.nlm.nih.gov The imidazoline compound RX871024 glucose-dependently potentiates the release of insulin
in pancreatic islets and beta-cell lines. This activity of the compound is not related to its action
by stimulating alpha 2-adrenoceptors and I1- and I2-imidazoline receptors. There are at ... Cited by 15 - Related articles - All 3 versions
SV Zaitsev, AM Efanov, IB Efanova, O Larsson, CG … - Diabetes, 1996 - Am Diabetes Assoc A novel imidazoline compound, RX871024, was used to investigate the mechanisms by which
imidazoline derivatives promote insulin secretion in rat pancreatic beta-cells and HIT T15
cells. RX871024 stimulated insulin release from rat pancreatic beta-cells and HIT T15 ... Cited by 94 - Related articles - BL Direct - All 7 versions
VV Sharoyko, II Zaitseva, M Varsanyi, N Portwood, … - … and Biophysical Research …, 2005 - Elsevier The monomeric G-protein, Rhes, is a candidate imidazoline-regulated molecule involved in mediating
the insulin secretory response to efaroxan [SL Chan, LK Monks, H. Gao, P. Deaville, NG
Morgan, Identification of the monomeric G-protein, Rhes, as an efaroxan-regulated ... Cited by 5 - Related articles - All 4 versions
M Høy, HL Olsen, HS Andersen, K Bokvist, K … - European journal of …, 2003 - Elsevier We have investigated the effects of the novel imidazoline compound (+)-2-(2-(4,5-dihydro-1H
-imidazol-2-yl)-thiopene-2-yl-ethyl)-pyridine (NNC77-0074) on stimulus-secretion coupling in
isolated pancreatic α- and β-cells. NNC77-0074 stimulated glucose-dependent insulin ... Cited by 17 - Related articles - All 5 versions
CG Ostenson, J Pigon, JC Doxey, S Efendic - Journal of Clinical …, 1988 - Endocrine Soc Studies with phentolamine, an -adrenergic antagonist, in normal subjects and diabetic patients
have indicated that insulin secretion may be inhibited by tonic -adrenergic stimulation of pancreatic
B-cells. We evaluated, with the use of the highly selective 2 -adrenoceptor antagonist ... Cited by 40 - Related articles - All 3 versions
I Rustenbeck, L Leupolt, R Kowalewski, A … - … archives of pharmacology, 1999 - Springer Abstract Imidazolines are regarded as a pharmacological group of insulin secretagogues with
one uniform mecha- nism of action, namely closure of ATP-dependent K ... Key words Imidazoline
compounds · Insulin secretion · Cytosolic calcium concentration · Plasma membrane ... Cited by 15 - Related articles - BL Direct - All 4 versions
