HP Harding, D Ron - Diabetes, 2002 - Am Diabetes Assoc The early steps of insulin biosynthesis occur in the endoplasmic reticulum (ER), and the β-cell
has a highly developed and active ER. All cells regulate the capacity of their ER to fold and process
client proteins and they adapt to an imbalance between client protein load and folding ... Cited by 173 - Related articles - BL Direct - All 4 versions
- ►nih.gov S Oyadomari, A Koizumi, K Takeda, T … - Journal of Clinical …, 2002 - Am Soc Clin Investig Overload of pancreatic β cells in conditions such as hyperglycemia, obesity, and long-term treatment
with sulfonylureas leads to β cell exhaustion and type 2 diabetes. Because β cell mass declines
under these conditions, apparently as a result of apoptosis, we speculated that overload ... Cited by 283 - Related articles - BL Direct - All 8 versions
- ►nyu.edu [PDF] HP Harding, H Zeng, Y Zhang, R Jungries, P Chung, H … - Molecular cell, 2001 - Elsevier The protein kinase PERK couples protein folding in the endoplasmic reticulum (ER) to polypeptide
biosynthesis by phosphorylating the α subunit of eukaryotic translation initiation factor 2
(eIF2α), attenuating translation initiation in response to ER stress. PERK is highly ... Cited by 362 - Related articles - All 13 versions
S Oyadomari, E Araki, M Mori - Apoptosis, 2002 - Springer Apoptotic cell death in pancreatic β -cells is involved in the pathogenesis of diabetes. Signals
from death recep- tors and DNA damage have been widely accepted as be- ing triggers of apoptosis
in β -cells. Recent studies indi- cated that the endoplasmic reticulum (ER) can sense and ... Cited by 217 - Related articles - BL Direct - All 4 versions
- ►nih.gov D Ron - Journal of Clinical Investigation, 2002 - Am Soc Clin Investig From the perspective of protein biosynthesis, the endoplasmic reticulum (ER) can be viewed
as a processing plant for folding and posttranslational modification of secreted and integral membrane
proteins. At any given time, the load of client proteins that the ER must handle is set by ... Cited by 306 - Related articles - BL Direct - All 14 versions
- ►ebmonline.org E Araki, S Oyadomari, M Mori - Experimental Biology and Medicine, 2003 - SEBM Diabetes is caused by impaired insulin secretion in pancreatic ß-cells and peripheral insulin
resistance. Overload of pancreatic ß-cells leads to ß-cell exhaustion and finally to the development
of diabetes. Reduced ß-cell mass is evident in type 2 diabetes, and apoptosis is ... Cited by 82 - Related articles - BL Direct - All 3 versions
- ►nih.gov P Zhang, B McGrath, S Li, A Frank, F Zambito, … - Molecular and Cellular …, 2002 - Am Soc Microbiol Phosphorylation of eukaryotic initiation factor 2 (eIF-2 ) is typically associated with stress responses
and causes a reduction in protein synthesis. However, we found high phosphorylated eIF-2
(eIF-2 [P]) levels in nonstressed pancreata of mice. Administration of glucose stimulated a ... Cited by 173 - Related articles - BL Direct - All 6 versions
E ARAKI, S OYADOMARI, M MORI - Internal Medicine, 2003 - Journal@rchive Pancreatic p-cells are strongly engaged in protein se- cretion and have highly developed endoplasmic
reticulum (ER). Proper folding of polypeptide into a three- dimensional structure is essential for
cellular function and protein malfolding can threaten cell survival. Various conditions can ... Cited by 47 - Related articles - BL Direct - All 5 versions
N PLONGTHONGKUM - 2004 - mulinet9.li.mahidol.ac.th Page 1. CHARACTERIZATION OF A PUTATIVE DROSOPHILA XBP1 : A TRANSCRIPTION
FACTOR REGULATED BY UNFOLDED PROTEIN RESPONSE PATHWAY (UPR) NONGLUK
PLONGTHONGKUM A THESIS SUBMITTED IN PARTIAL FULFILLMENT ... Cited by 1 - Related articles - All 2 versions
- ►nyu.edu [PDF] HP Harding, M Calfon, F Urano, I Novoa, D … - Annual review of cell and …, 2002 - Annual Reviews ▪ Abstract Cells monitor the physiological load placed on their endoplasmic reticulum (ER) and
respond to perturbations in ER function by a process known as the unfolded protein response
(UPR). In metazoans the UPR has a transcriptional component that up-regulates ... Cited by 467 - Related articles - BL Direct - All 7 versions
