M Unno, K Nata, N Noguchi, Y Narushima, T Akiyama, … - Diabetes, 2002 - Am Diabetes Assoc Reg (regenerating gene) was isolated as a gene specifically expressed in regenerating
islets. We have demonstrated in vitro and in vivo that the exogenous addition of rat and human
Reg gene products, Reg/REG proteins, induced β-cell replication via the Reg receptor ... Cited by 51 - Related articles - BL Direct - All 6 versions
- ►endojournals.org DJ Gross, L Weiss, I Reibstein, J van den Brand, H … - Endocrinology, 1998 - Endocrine Soc Oral linomide, (quinoline-3-carboxamide), has been shown to prevent autoimmune insulitis,
islet destruction, and diabetes in NOD mice treated at an early stage of the disease, but confers
only partial protection in animals with advanced disease. Reg protein, the gene product of ... Cited by 47 - Related articles - BL Direct - All 3 versions
- ►daegu.ac.kr [PDF] H Okamoto - Journal of hepato-biliary-pancreatic surgery, 1999 - Springer Abstract: Pancreatic β-cells of the islets of Langerhans are the only cells that produce insulin
in humans, as well as in most animals, but they have been thought to have a limited capacity
for regeneration, which is a predisposing factor for the devel- opment of diabetes mellitus. ... Cited by 104 - Related articles - BL Direct - All 5 versions
S Meili, R Graf, A Perren, M Schiesser, D Bimmler - Cell and tissue research, 2003 - Springer Page 1. Cell Tissue Res (2003) 312:291–299 DOI 10.1007/s00441-003-0733-1 REGULAR
ARTICLE Severin Meili · Rolf Graf · Aurel Perren · Marc Schiesser · Daniel Bimmler
Secretory apparatus assessed by analysis of pancreatic secretory ... Cited by 11 - Related articles - BL Direct - All 3 versions
BK Dieckgraefe, DL Crimmins, V Landt, C … - Journal of Investigative …, 2002 - journals.lww.com Background: The pathophysiology of inflammatory bowel disease (IBD) reflects a balance between
mucosal injury re- lated to an ongoing inflammatory process and mucosal re- parative
mechanisms. Proreparative mucosal factors may offer new therapeutic paradigms. ... Cited by 53 - Related articles - BL Direct - All 4 versions
R Graf, M Schiesser, A Lüssi, P Went, GA Scheele, … - Journal of Surgical …, 2002 - Elsevier Background. Pancreatic stone protein (PSP/reg) is a constitutively secreted protein in pancreatic
juice. Pancreatitis-associated protein (PAP) belongs to the same family of proteins. PAP is highly
increased during acute pancreatitis, while no exact data exist regarding PSP/reg protein ... Cited by 37 - Related articles - BL Direct - All 6 versions
M Abe, K Nata, T Akiyama, NJ Shervani, S Kobayashi, … - Gene, 2000 - Elsevier Regenerating gene (Reg), first isolated from a regenerating islet cDNA library, encodes a secretory
protein with a growth stimulating effect on pancreatic β cells that ameliorates the diabetes of
90% depancreatized rats and non-obese diabetic mice. Reg and Reg-related genes have ... Cited by 40 - Related articles - All 4 versions
H Okamoto, S Takasawa - Diabetes, 2002 - ncbi.nlm.nih.gov Twenty years ago, we first proposed our hypothesis on beta-cell damage and its prevention
(the Okamoto model), according to which poly(ADP-ribose) synthetase/polymerase (PARP) activation
is critically involved in the consumption of NAD(+), leading to energy depletion and cell ... Cited by 50 - Related articles - BL Direct
- ►jbc.org [PDF] K Terazono, H Yamamoto, S Takasawa, K Shiga, Y … - Journal of Biological …, 1988 - ASBMB Administration of poly(ADP-ribose) synthetase in- hibitors such as nicotinamide to 90% depancreatized
rats induces regeneration of pancreatic islets, thereby ameliorating the surgical diabetes
(Yonemura, Y., Takashima, T., Miwa, K., Miyazaki, I., Yamamoto, H., and Okamoto, H. ... Cited by 246 - Related articles - All 7 versions
M Schiesser, D Bimmler, TW Frick, R Graf - Pancreas, 2001 - journals.lww.com Summary: Pancreatitis-associated protein (PAP), a secretory acute-phase protein of the pancreatic
acinar cell, is highly up- regulated early in acute pancreatitis. PAP expression returns to undetectable
levels when the pancreas recovers. In the rat, three isoforms of PAP are known, all of ... Cited by 26 - Related articles - BL Direct - All 5 versions
