JL Evans, ID Goldfine, BA Maddux, GM … - Diabetes, 2003 - Am Diabetes Assoc In both type 1 and type 2 diabetes, diabetic complications in target organs
arise from chronic elevations of glucose. The pathogenic effect of high glucose,
possibly in concert with fatty acids, is mediated to a significant extent ... Cited by 365 - Related articles - BL Direct - All 10 versions
- ►nutravene.com [PDF] AOSAS Pathways - Diabetes, 2003 - Am Diabetes Assoc In both type 1 and type 2 diabetes, diabetic complica- tions in target organs
arise from chronic elevations of glucose. The pathogenic effect of high glucose,
possibly in concert with fatty acids, is mediated to a significant extent ... Related articles - All 5 versions
- ►diabetesjournals.org BA Maddux, W See, JC Lawrence, AL Goldfine, … - Diabetes, 2001 - Am Diabetes Assoc In diabetic patients, α-lipoic acid (LA) improves skeletal muscle glucose
transport, resulting in increased glucose disposal; however, the molecular
mechanism of action of LA is presently unknown. We studied the effects of ... Cited by 156 - Related articles - BL Direct - All 13 versions
K Sakai, K Matsumoto, T Nishikawa, M Suefuji … - Biochemical and biophysical research communications, 2003 - Elsevier Pancreatic β-cells exposed to hyperglycemia produce reactive oxygen species
(ROS). Because β-cells are sensitive to oxidative stress, excessive ROS may
cause dysfunction of β-cells. Here we demonstrate that mitochondrial ROS ... Cited by 130 - Related articles - BL Direct - All 6 versions
RP Robertson, J Harmon, PO Tran, Y Tanaka, … - Diabetes, 2003 - Am Diabetes Assoc Chronic exposure to hyperglycemia can lead to cellular dysfunction that may
become irreversible over time, a process that is termed glucose toxicity. Our
perspective about glucose toxicity as it pertains to the pancreatic β-cell ... Cited by 313 - Related articles - BL Direct - All 10 versions
- ►endojournals.org JL Evans, ID Goldfine, BA Maddux, GM … - Endocrine Reviews, 2002 - Endocrine Soc In both type 1 and type 2 diabetes, the late diabetic complications in nerve,
vascular endothelium, and kidney arise from chronic elevations of glucose and
possibly other metabolites including free fatty acids (FFA). Recent ... Cited by 593 - Related articles - BL Direct - All 18 versions
- ►jbc.org P Maechler, L Jornot, CB Wollheim - Journal of Biological Chemistry, 1999 - ASBMB The effects of a transient exposure to hydrogen peroxide (10 min at 200 µM H 2
O 2 ) on pancreatic beta cell signal transduction and insulin secretion have
been evaluated. In rat islets, insulin secretion evoked by glucose (16.7 ... Cited by 117 - Related articles - BL Direct - All 6 versions
M Tiedge, S Lortz, J Drinkgern, S Lenzen - Diabetes, 1997 - Am Diabetes Assoc Antioxidant enzyme expression was determined in rat pancreatic islets and RINm5F
insulin-producing cells on the level of mRNA, protein, and enzyme activity in
comparison with 11 other rat tissues. Although superoxide dismutase ... Cited by 331 - Related articles - BL Direct - All 6 versions
A Rudich, A Tirosh, R Potashnik, R Hemi, H … - DIABETES-NEW YORK-, 1998 - Am Diabetes Assoc Prolonged exposure of 3T3-L1 adipocytes to micromo- lar concentrations of H 2 O
2 results in an impaired response to the acute metabolic effects of insulin. In
this study, we further characterized the mechanisms by which oxidative ... Cited by 210 - Related articles - BL Direct - All 4 versions
- ►nih.gov Y Tanaka, POT Tran, J Harmon, RP … - Proceedings of the National Academy of Sciences of …, 2002 - National Acad Sciences Antioxidant drugs have been reported to protect pancreatic islets from the
adverse effects of chronic exposure to supraphysiological glucose
concentrations. However, glucose has not been shown to increase ... Cited by 113 - Related articles - BL Direct - All 10 versions
