- ►diabetesjournals.org AM Schmeichel, JD Schmelzer, PA Low - Diabetes, 2003 - Am Diabetes Assoc We evaluated the effects of chronic hyperglycemia on L5 dorsal root ganglion
(DRG) neurons using immunohistochemical and electrophysiologic techniques for
evidence of oxidative injury. Experimental diabetic neuropathy was induced ... Cited by 147 - Related articles - BL Direct - All 10 versions
JW Russell, KA Sullivan, AJ Windebank, DN … - Neurobiology of disease, 1999 - Elsevier Recent clinical trials indicate that the severity of diabetic neuropathy is
correlated with the level of patient glycemic control. In the current study,
hyperglycemia induces apoptotic changes in dorsal root ganglion neurons and ... Cited by 177 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org C Cheng, DW Zochodne - Diabetes, 2003 - Am Diabetes Assoc Long-term experimental diabetes may best model the prominent and irreversible
sensory deficits of chronic human diabetic polyneuropathy. Whereas irretrievable
loss of sensory neurons, if present, would be an unfortunate feature of the ... Cited by 78 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] S Srinivasan, M Stevens, JW Wiley - Diabetes, 2000 - Am Diabetes Assoc We hypothesized that diabetic sensory neuropathy is associated with activation
of apoptosis and concomitant mitochondrial dysfunction. Studies were performed
in excised intact and acutely dissociated dorsal root gan- glion (DRG) ... Cited by 118 - Related articles - BL Direct - All 5 versions
- ►fasebj.org JW RUSSELL, D GOLOVOY, AM VINCENT, … - The FASEB Journal, 2002 - FASEB The current study examines the association between glucose induction of reactive
oxygen species (ROS), mitochondrial (Mt) depolarization, and programmed cell
death in primary neurons. In primary dorsal root ganglion (DRG) neurons, 45 ... Cited by 114 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org M Kishi, J Tanabe, JD Schmelzer, PA Low - Diabetes, 2002 - Am Diabetes Assoc Chronic hyperglycemia results in a predominantly sensory neuropathy. Recent
studies suggest that dorsal root ganglion (DRG) neurons comprise a specific
target and may be responsible for the important complication of diabetic ... Cited by 38 - Related articles - BL Direct - All 4 versions
AM Vincent, M Brownlee, JW Russell - ANNALS-NEW YORK ACADEMY OF SCIENCES, 2002 - interscience.wiley.com Abstract: Recent evidence in both animal models and human sural nerve biopsies
indicates an association with oxidative stress, mitochondrial (Mt) membrane
depolarization (MMD), and induction of programmed cell death (PCD). In ... Cited by 130 - Related articles - BL Direct - All 3 versions
L Hounsom, R Corder, J Patel, DR Tomlinson - Diabetologia, 2001 - Springer Oxidative stress has been suggested to be a causal factor of diabetic
complications [1±3]. Diabetes com- promises natural antioxidant defence
systems, lower- ing tissue GSH (reduced glutathione), ascorbic acid, ... Cited by 31 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org LJ Coppey, JS Gellett, EP Davidson, JA … - Diabetes, 2001 - Am Diabetes Assoc We have shown that diabetes-induced reduction in endoneurial blood flow (EBF)
and impaired endothelium-dependent vascular relaxation precede slowing of motor
nerve conduction velocity (MNCV) and decreased sciatic nerve Na + /K + ... Cited by 129 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org TJ Huang, SA Price, L Chilton, NA Calcutt, … - Diabetes, 2003 - Am Diabetes Assoc Mitochondrial dysfunction has been proposed as a mediator of neurodegeneration
in diabetes complications. The aim of this study was to determine whether
deficits in insulin-dependent neurotrophic support contributed to ... Cited by 55 - Related articles - BL Direct - All 5 versions
