- ►diabetesjournals.org M Kobayashi, T Ohno, A Tsuji, M Nishimura, F Horio - Diabetes, 2003 - Am Diabetes Assoc Type 2 diabetes in humans is not a single gene disorder but a multifactorial disease caused
by the interaction of multiple genes and environmental factors. Recombinant inbred (RI) strains
are a powerful tool for analyzing not only single genetic traits but also multifactorial ... Cited by 17 - Related articles - BL Direct - All 5 versions
M Kobayashi, F Io, T Kawai, M Nishimura, T Ohno, … - Bioscience, …, 2004 - J-STAGE SMXA-5 Mouse as a Diabetic Model Susceptible to Feeding a High-fat Diet ... Misato K OBAYASHI
, 1 Fusayo I O , 1 Takahiro K AWAI , 1 Masahiko N ISHIMURA , 2 ... Tamio O HNO , 2 and Fumihiko
H ORIO 1;y ... 1 Department of Applied Molecular Bioscience, Graduate School of ... Cited by 9 - Related articles - BL Direct - All 5 versions
- ►tokushima-u.ac.jp [PDF] S Takeshita, M Moritani, K Kunika, H Inoue, M Itakura - Mammalian Genome, 2006 - Springer Abstract To identify novel genetic modifiers of type 2 dia- betes (T2D), we performed quantitative
trait loci (QTL) analysis on F 2 progeny of hypoinsulinemic diabetic Akita mice, heterozygous
for the Ins2 gene Cys96Tyr mutation, and nondiabetic A/J mice. We generated 625 ... Cited by 8 - Related articles - BL Direct - All 5 versions
RVP Anunciado, F Horio, T Ohno, S Tanaka, M … - EXPERIMENTAL …, 2000 - sciencelinks.jp Abstract;We discovered two mouse strains(SMXA-5 and SMXA-9) with hyperinsulinemia among
the substrains and progenitor strains(SM/J and A/J) of the SMXA recombinant inbred(RI)
strains, and characterized the two strains at 20 weeks of age. SMXA-5(mean.+-.SEM: ... Cited by 10 - Related articles - Cached - BL Direct - All 3 versions
M Kobayashi, F Io, T Kawai, M Kumazawa, H Ikegami, … - Diabetologia, 2006 - Springer Page 1. Diabetologia (2006) 49: 486–495 DOI 10.1007/s00125-005-0121-3 ARTICLE
M. Kobayashi . F. Io . T. Kawai . M. Kumazawa . H. Ikegami . M. Nishimura . T. Ohno . F.
Horio Major quantitative trait locus on chromosome 2 for glucose ... Cited by 10 - Related articles - BL Direct - All 2 versions
RV Anunciado, T Ohno, M Mori, A Ishikawa, S … - … for Laboratory Animal …, 2000 - ncbi.nlm.nih.gov In the SMXA recombinant inbred (RI) strains, we measured body weight, blood insulin and lipid
(triglyceride, total cholesterol and phospholipid) levels in each strain. In the five traits, mean values
of substrains varied remarkably and showed a continuous spectrum of distribution, ... Cited by 32 - Related articles - BL Direct - All 3 versions
M Nishimura, N Hirayama, T Serikawa, K Kanehira, Y … - Mammalian Genome, 1995 - Springer Since Bailey (1971) developed the first set of recombinant inbred (RI) strains, CXB, from the inbred
strains BALB/cBy and C57BL/ 6By, at least 24 sets of RI strains have been established (Taylor
1989). These RI strains have proved to be powerful tools in study- ing the genetic basis of ... Cited by 27 - Related articles - BL Direct - All 2 versions
- ►tokushima-u.ac.jp [PDF] M Moritani, K Togawa, H Yaguchi, Y Fujita, Y … - Genomics, 2006 - Elsevier To identify the disease-susceptibility genes of type 2 diabetes, we performed quantitative trait
loci (QTL) analysis in F 2 populations generated from a BKS.Cg-m+/+Lepr db and C3H/HeJ
intercross, taking advantage of genetically determined obesity and diabetes traits ... Cited by 6 - Related articles - All 5 versions
T Masuyama, M Fuse, N Yokoi, M Shinohara, H … - … and Biophysical Research …, 2003 - Elsevier The Spontaneously Diabetic Torii (SDT) rat has recently been established as a new rat model
of nonobese type 2 diabetes. In this study, we characterized diabetic features in SDT rats, and
performed quantitative trait locus (QTL) analysis for glucose intolerance using 319 male ... Cited by 27 - Related articles - All 4 versions
J Suto, K Sekikawa - International journal of obesity, 2002 - cat.inist.fr KK and KK-Ay mice serve as animal models of non-insulin-dependent diabetes mellitus with
moderate obesity. Quantitative trait locus(QTL) analysis was performed to identify gene loci that
account for fasting hyperglycemia, glucose intolerance and plasma insulin in 91 F 2 ... Cited by 9 - Related articles - BL Direct - All 3 versions
