- ►diabetesjournals.org RJ Gum, LL Gaede, SL Koterski, M Heindel, JE … - Diabetes, 2003 - Am Diabetes Assoc Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of insulin
receptor (IR) signal transduction and a drug target for treatment of type 2
diabetes. Using PTP1B antisense oligonucleotides (ASOs), effects of ... Cited by 110 - Related articles - BL Direct - All 6 versions
- ►pnas.org BA Zinker, CM Rondinone, JM Trevillyan, RJ … - Proceedings of the National Academy of Sciences, 2002 - National Acad Sciences The role of protein-tyrosine phosphatase 1B (PTP1B) in diabetes was investigated
using an antisense oligonucleotide in ob/ob and db/db mice. PTP1B antisense
oligonucleotide treatment normalized plasma glucose levels, postprandial ... Cited by 194 - Related articles - BL Direct - All 13 versions
- ►diabetesjournals.org CM Rondinone, JM Trevillyan, J Clampit, RJ … - Diabetes, 2002 - Am Diabetes Assoc Protein tyrosine phosphatase 1B (PTP1B) has been implicated as a negative
regulator of insulin action. Overexpression of PTP1B protein has been observed
in insulin-resistant states associated with obesity. Mice lacking a ... Cited by 70 - Related articles - BL Direct - All 5 versions
JE Clampit, JL Meuth, HT Smith, RM Reilly, … - Biochemical and Biophysical Research …, 2003 - Elsevier Protein-tyrosine phosphatase-1B (PTP1B) has been implicated as a negative
regulator of insulin signaling. PTP1B dephosphorylates the insulin receptor and
insulin receptor substrates (IRS-1/2), inhibiting the insulin-signaling ... Cited by 30 - Related articles - BL Direct - All 4 versions
- ►leptipro.org [PDF] JM Zabolotny, FG Haj, YB Kim, HJ Kim, GI … - Journal of Biological Chemistry, 2004 - ASBMB Previous studies implicate protein-tyrosine phosphatase 1B (PTP1B) and leukocyte
antigen-related phosphatase (LAR) as negative regulators of insulin signaling.
The expression and/or activity of PTP1B and LAR are increased in muscle of ... Cited by 55 - Related articles - BL Direct - All 8 versions
S Shimizu, S Ugi, H Maegawa, K Egawa, Y … - Journal of Biological Chemistry, 2003 - ASBMB Like hyperglycemia, postprandial (diet-induced) hypertriglyceridemia is thought
to play crucial roles in the pathogenesis of insulin resistant/metabolic
syndrome. Sterol regulatory element-binding protein-1 (SREBP-1) is a key ... Cited by 31 - Related articles - BL Direct - All 4 versions
- ►nih.gov LD Klaman, O Boss, OD Peroni, JK Kim, JL … - Molecular and cellular biology, 2000 - Am Soc Microbiol Protein-tyrosine phosphatase 1B (PTP-1B) is a major protein-tyrosine phosphatase
that has been implicated in the regulation of insulin action, as well as in
other signal transduction pathways. To investigate the role of PTP-1B in ... Cited by 531 - Related articles - BL Direct - All 15 versions
- ►nih.gov S Galic, C Hauser, BB Kahn, FG Haj, BG Neel, … - Molecular and Cellular Biology, 2005 - Am Soc Microbiol The protein tyrosine phosphatase PTP1B is a negative regulator of insulin
signaling and a therapeutic target for type 2 diabetes. Our previous studies
have shown that the closely related tyrosine phosphatase TCPTP might also ... Cited by 47 - Related articles - All 11 versions
- ►jbc.org K Egawa, H Maegawa, S Shimizu, K Morino, Y … - Journal of Biological Chemistry, 2001 - ASBMB Insulin signaling is regulated by tyrosine phosphorylation of the signaling
molecules, such as the insulin receptor and insulin receptor substrates (IRSs).
Therefore, the balance between protein-tyrosine kinases and ... Cited by 62 - Related articles - BL Direct - All 3 versions
- ►jbc.org MR Calera, G Vallega, PF Pilch - Journal of Biological Chemistry, 2000 - ASBMB Protein-tyrosine phosphatases (PTPases) play a key role in maintaining the
steady-state tyrosine phosphorylation of the insulin receptor (IR) and its
substrate proteins such as insulin receptor substrate 1 (IRS-1). However, ... Cited by 66 - Related articles - BL Direct - All 3 versions
