AK Azevedo-Martins, S Lortz, S Lenzen, R Curi … - Diabetes, 2003 - Am Diabetes Assoc Proinflammatory cytokines (interleukin-1ß [IL-1ß], tumor necrosis factor-
[TNF- ], and -interferon [IFN- ]) initiate a variety of signal cascades in
pancreatic ß-cells that affect the expression level of genes involved in ... Cited by 61 - Related articles - BL Direct - All 4 versions
M Tiedge, S Lortz, R Munday, S Lenzen - Diabetologia, 1999 - Springer The mechanisms of beta-cell destruction in autoim- mune diabetes comprise
specific cell-mediated mech- anisms as well as humoral factors like cytokines
[1±4]. The latter initiate complex cellular signal cascades which lead to ... Cited by 71 - Related articles - BL Direct - All 4 versions
S Lortz, M Tiedge, T Nachtwey, AE Karlsen, J … - DIABETES-NEW YORK-, 2000 - Am Diabetes Assoc Nitric oxide (NO) and reactive oxygen species (ROS) are crucial elements in
cytokine-mediated -cell destruc- tion. In insulin-producing RINm5F cells,
overexpression of cytoprotective enzymes provides significant protection ... Cited by 126 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org E Gurgul, S Lortz, M Tiedge, A Jörns, S … - Diabetes, 2004 - Am Diabetes Assoc Insulin-producing cells are known for their extremely low antioxidant equipment
with hydrogen peroxide (H 2 O 2 )-inactivating enzymes. Therefore, catalase was
stably overexpressed in mitochondria and for comparison in the cytoplasmic ... Cited by 42 - Related articles - BL Direct - All 4 versions
N Giannoukakis, WA Rudert, M Trucco, PD … - Journal of Biological Chemistry, 2000 - ASBMB Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that inhibits β cell
function and promotes Fas-triggered apoptosis. IL-1β is thought to act early in
the initiation of the autoimmune destruction of pancreatic β cells in type ... Cited by 127 - Related articles - BL Direct - All 4 versions
S Lortz, E Gurgul-Convey, S Lenzen, M … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Free radicals generated in mi- tochondria play a
crucial role in the toxic effects of cy- tokines upon insulin-producing cells.
This study therefore investigated the role of manganese superoxide ... Cited by 11 - Related articles - BL Direct - All 3 versions
S Bertera, ML Crawford, AM Alexander, GD … - Diabetes, 2003 - Am Diabetes Assoc Islet transplantation is a promising cure for diabetes. However, inflammation,
allorejection, and recurrent autoimmune damage all may contribute to early graft
loss. Pancreatic islets express lower levels of antioxidant genes than most ... Cited by 68 - Related articles - BL Direct - All 4 versions
- ►inotekcorp.com [PDF] WL Suarez-Pinzon, JG Mabley, K Strynadka, … - Journal of autoimmunity, 2001 - Elsevier Peroxynitrite (ONOO − ) is a highly reactive oxidant produced by the
interaction of the free radicals superoxide (O•−2) and nitric oxide (NO •
). In a previous study, we found that peroxynitrite is formed in islet ... Cited by 55 - Related articles - BL Direct - All 8 versions
MI Darville, DL Eizirik - Diabetologia, 1998 - Springer Type I (insulin-dependent) diabetes mellitus results from a selective
destruction of the pancreatic insu- lin-producing beta cells. Cytokines,
especially inter- leukin-1b (IL-1b), could play an important role in im- ... Cited by 113 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org [PDF] M Tiedge, S Lortz, R Munday, S Lenzen - Diabetes, 1998 - Am Diabetes Assoc To determine the importance of different antioxidative enzymes for the defense
status of insulin-producing cells, the effects of stable overexpression of
glutathione peroxidase (Gpx), catalase (Cat), or Cu/Zn superoxide dismutase ... Cited by 96 - Related articles - BL Direct - All 5 versions
