S Kashyap, R Belfort, A Gastaldelli, T Pratipanawatr, R … - Diabetes, 2003 - Am Diabetes Assoc Acute elevations in free fatty acids (FFAs) stimulate insulin secretion, but prolonged lipid exposure
impairs β-cell function in both in vitro studies and in vivo animal studies. In humans data are
limited to short-term (≤48 h) lipid infusion studies and have led to conflicting results. We ... Cited by 156 - Related articles - BL Direct - All 4 versions
H Storgaard, CB Jensen, AA Vaag, A Vølund, S … - Metabolism, 2003 - Elsevier We studied the effect of a low-grade short- and long-term 20% Intralipid infusion (0.4 mL −1 ·
kg −1 · h −1 ) on insulin secretion and insulin action in 15 elderly obese men; 7 glucose intolerant
first-degree relatives of type 2 diabetic patients (impaired glucose tolerance [IGT] ... Cited by 31 - Related articles - All 13 versions
G Boden, X Chen, J Rosner, M Barton - Diabetes, 1995 - Am Diabetes Assoc To determine the effects of prolonged elevation of plasma free fatty acids (FFAs) on insulin
secretion, we infused Liposyn II (4.3 mumol.kg-1.min-1) plus heparin (0.4 U.kg-1.min-1) intravenously
into six healthy volunteers for 48 h. Another six volunteers received saline infusions and ... Cited by 188 - Related articles - BL Direct - All 5 versions
- ►endojournals.org CB Jensen, H Storgaard, JJ Holst, F Dela, S … - Journal of Clinical …, 2003 - Endocrine Soc We examined the simultaneous effects of a 24-h low-grade Intralipid infusion on peripheral glucose
disposal, intracellular glucose partitioning and insulin secretion rates in twenty young men, by
2-step hyperinsulinemic euglycemic clamp [low insulin clamp (LI), 10 mU/m 2 ·min; high ... Cited by 24 - Related articles - BL Direct - All 5 versions
A Carpentier, A Giacca, GF Lewis - Diabetologia, 2001 - Springer In recent years, there has been increasing interest in the effects of NEFAs on pancreatic
beta-cell func- tion [1±5]. While it is generally acceptedthat the acute increase in plasma NEFAs
enhances glucose- stimulatedinsulin secretion (GSIS) [6±8], the effect Cited by 18 - Related articles - BL Direct - All 4 versions
A Carpentier, SD Mittelman, RN Bergman, A Giacca, … - Diabetes, 2000 - Am Diabetes Assoc Our recent in vivo observations in healthy nonobese humans have demonstrated that prolonged
elevation of plasma free fatty acids (FFAs) results in diminished glucose-stimulated insulin secretion
(GSIS) when the F FA-mediated decrease in insulin sensitivity is taken into account. In the ... Cited by 94 - Related articles - BL Direct - All 5 versions
- ►physiology.org [PDF] K Cusi, S Kashyap, A Gastaldelli, M Bajaj, … - American Journal of …, 2007 - Am Physiological Soc Page 1. 1 Effects on Insulin Secretion and Insulin Action of a 48-Hour Reduction of Plasma Free
Fatty Acids with Acipimox in Non-Diabetic Subjects Genetically Predisposed to Type 2 Diabetes
Kenneth Cusi*§, Sangeeta Kashyap*, Amalia Gastaldelli*, Mandeep Bajaj*, ... Cited by 3 - Related articles
G Boden, X Chen - DIABETES-NEW YORK-, 1999 - Am Diabetes Assoc The objective of this study was to assess the role of free fatty acids (FFAs) as insulin secretagogues
in patients with type 2 diabetes. To this end, basal insulin secretion rates (ISR) in response to
acute increases in plasma F FAs were evaluated in patients with type 2 diabetes and in ... Cited by 55 - Related articles - BL Direct - All 5 versions
- ►physiology.org K Cusi, S Kashyap, A Gastaldelli, M Bajaj, … - American Journal of …, 2007 - Am Physiological Soc Elevated plasma FFA cause -cell lipotoxicity and impair insulin secretion in nondiabetic subjects
predisposed to type 2 diabetes mellitus [T2DM; ie, with a strong family history of T2DM
(FH+)] but not in nondiabetic subjects without a family history of T2DM. To determine ... Cited by 16 - Related articles - BL Direct - All 4 versions
G Boden, X Chen, N Iqbal - DIABETES-NEW YORK-, 1998 - Am Diabetes Assoc The objective of this study was to determine whether basal plasma free fatty acid (FFA) concentrations
a ffect basal insulin secretion rates (ISRs). Effects of F FA levels on basal ISRs were evaluated
by lowering basal plasma FFA levels with nicotinic acid (NA) (100–150 mg po, q 30 min 4 ... Cited by 81 - Related articles - BL Direct - All 5 versions
