RD Carr, CL Brand, TB Bodvarsdottir, JB … - Diabetes, 2003 - Am Diabetes Assoc A novel potassium channel opener compound, NN414, selective for the SUR1/Kir6.2
subtype of the ATP-sensitive potassium channel, was used to examine the effect
of reducing β-cell workload in the male Vancouver diabetic fatty (VDF) ... Cited by 30 - Related articles - BL Direct - All 4 versions
K Skak, CF Gotfredsen, D Lundsgaard, JB … - Diabetes, 2004 - Am Diabetes Assoc Treatment with ATP-sensitive K + channel openers (KCOs) leads to inhibition of
insulin secretion and metabolic “rest” in β-cells. It is hypothesized that
in type 1 diabetes this may reduce β-cell death resulting from metabolic ... Cited by 26 - Related articles - BL Direct - All 4 versions
M Guldstrand, V Grill, A Björklund, PE Lins, … - Diabetes & metabolism, 2002 - cat.inist.fr Objectif: Notre but était de distinguer les effets bénéfiques de la mise au
repos des cellules bêta des autres effets de la correction de l'hyperglycémie.
Pour cela nous avons utilisé le diazoxide qui bloque de façon réversible ... Cited by 40 - Related articles - BL Direct - All 3 versions
M Dabrowski, T Larsen, FM Ashcroft, J Bondo … - Diabetologia, 2003 - Springer Aims/hypothesis. We investigated the pharmacological properties of two novel ATP
sensitive potassium (K ATP ) channel openers, 6-Chloro-3-isopropylamino-
4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide (NNC 55-0118) and ... Cited by 29 - Related articles - BL Direct - All 3 versions
FE Nielsen, TB Bodvarsdottir, A Worsaae, P … - J. Med. Chem, 2002 - pubs.acs.org 6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives
were synthesized and characterized as activators of adenosine 5'-triphosphate
(ATP) sensitive potassium (K ATP ) channels in the β-cells by measuring ... Cited by 33 - Related articles - BL Direct - All 4 versions
S Hiramatsu, A Höög, C Möller, V Grill - Metabolism, 2000 - Elsevier Prolonged hyperglycemia desensitizes β cells. A role for hyperglycemia-induced
excessive stimulation can be tested by diazoxide, which inhibits glucose-induced
insulin secretion. Using diazoxide, we have investigated in a rat ... Cited by 21 - Related articles - BL Direct - All 5 versions
- ►endojournals.org RA Ritzel, JB Hansen, JD Veldhuis, PC Butler - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc In health, most insulin is secreted in pulses. Type 2 diabetes mellitus (TTDM)
is characterized by impaired pulsatile insulin secretion with a defect in
insulin pulse mass. It has been suggested that this defect is partly due to ... Cited by 35 - Related articles - BL Direct - All 5 versions
… BMDPW Marie, HAFSS Sebille, ROJB Hansen - Journal of Medicinal Chemistry, 2003 - 万方数据资源系统 3-(Alkylamino)-7-halo-4H-1,2,4-benzothiadiazine 1,1-dioxides were synthesized,
and their activity on rat-insulin-secreting cells and rat aorta rings was
compared to that of the K_(ATP) channel activators diazoxide and pinacidil. ... Cited by 21 - Related articles - BL Direct - All 4 versions
M Matsuda, F Kawasaki, Y Mikami, Y Takeuchi … - European journal of pharmacology, 2002 - Elsevier In this study, we attempted to demonstrate the possibility of rescuing beta-cell
exhaustion by chronic intervention with an ATP-sensitive K + channel opener,
diazoxide, which reduces the stress of insulin secretion, using rats with ... Cited by 16 - Related articles - All 4 versions
R Alemzadeh, C Fledelius, T Bodvarsdottir, J … - Metabolism, 2004 - Elsevier Chronic attenuation of hyperinsulinemia by diazoxide (DZ), a K-adenosine
triphosphate (ATP) channel opener and an inhibitor of glucose-mediated insulin
secretion, improved glucose tolerance and lipid profile and decreased the ... Cited by 12 - Related articles - All 8 versions
