- ►diabetesjournals.org F Kamp, N Kizilbash, BE Corkey, PO Berggren … - Diabetes, 2003 - Am Diabetes Assoc Because sulfonylureas directly activate the exocytotic machinery, we were
interested in the extent to which these compounds penetrate the β-cell plasma
membrane and the underlying molecular mechanism(s). We now provide evidence ... Cited by 16 - Related articles - BL Direct - All 4 versions
G Marynissen, G Smets, G Klöppel, L … - Acta Diabetologica, 1992 - Springer Abstract. When rat pancreatic islets were exposed for 30 min at 37~ to tritiated
glibenclamide (2.5 gM) or glimepiride 0.5 gM), internalization of these hypogly-
caemic sulphonylureas in B and non-B cells was observed by autoradiography. ... Cited by 12 - Related articles - All 2 versions
E Renström, S Barg, F Thévenod, P Rorsman - Diabetes, 2002 - Am Diabetes Assoc Several reports indicate that hypoglycemic sulfonylureas augment Ca 2+
-dependent insulin secretion via mechanisms other than inhibition of the
ATP-sensitive K + channel. The effect involves a 65-kd protein in the ... Cited by 33 - Related articles - BL Direct - All 5 versions
- ►escholarship.org AJ Ball, JT McCluskey, PR Flatt, NH … - Pharmacological Research, 2004 - Elsevier Insulinotropic sulphonylureas such as tolbutamide and glibenclamide have found
widespread application in drug therapy of type 2 diabetes mellitus [1 and 2].
Following acute or short-term administration, they exert a hypoglycaemic ... Cited by 13 - Related articles - All 7 versions
X Geng, L Li, S Watkins, PD Robbins, P Drain - Diabetes, 2003 - Am Diabetes Assoc With ATP sites on K ir 6.2 that inhibit activity and ADP sites on SUR1 that
antagonize the inhibition, ATP-sensitive potassium channels (K ATP channels) are
designed as exquisite sensors of adenine nucleotide levels that signal ... Cited by 63 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org Z Ling, Q Wang, G Stangé… - Diabetes, 2006 - Am Diabetes Assoc Use of sulfonylureas in diabetes treatment is based on their insulin-releasing
effect on pancreatic β-cells. Prolonged action is known to degranulate
β-cells, but functional consequences have not been examined at the ... Cited by 2 - Related articles - BL Direct - All 5 versions
[CITATION] glibenclamideenclamide inhibits islet carnitine palmitoyltransferase 1 activity, leading to …
M Lehtihet, N Welsh, PO Berggren, GA Cook, … - Am J Physiol Endocrinol Metab, 2003 Cited by 2 - Related articles
T Kikuta, M Ohara-Imaizumi, M Nakazaki, C … - FEBS letters, 2005 - Elsevier To explore how the sulfonylurea receptor (SUR1) is involved in docking and
fusion of insulin granules, dynamic motion of single insulin secretory granules
near the plasma membrane was examined in SUR1 knock-out (Sur1KO) β-cells ... Cited by 2 - Related articles - All 5 versions
KJ Fanning, MS Roberts - Pharmaceutical research, 2007 - Springer Received June 13, 2006; accepted September 19, 2006; published online January
25, 2007 Purpose. To set up and validate a viable perfused rat pancreas model
suitable for pharmacokinetic studies. Materials and methods. We setup and ... Cited by 2 - Related articles - BL Direct - All 5 versions
HG Joost, S Holze - Cellular and Molecular Life Sciences (CMLS), 1978 - Springer 1 Acknowledgments. Financial support from the Whitehall Foundation, New York,
The Wellcome Foundation, UK (to JRC) and the Science Research Council
(Studentship to ME) is gratefully acknowledged. We thank Professor JH ... Cited by 3 - Related articles - All 2 versions
