- ►diabetesjournals.org NM Borradaile, LE de Dreu, MW Huff - Diabetes, 2003 - Am Diabetes Assoc The flavonoid naringenin improves hyperlipidemia and hyperglycemia in streptozotocin-treated
rats. In HepG2 human hepatoma cells, naringenin inhibits apolipoprotein B (apoB) secretion
primarily by inhibiting microsomal triglyceride transfer protein and enhances LDL receptor ... Cited by 37 - Related articles - BL Direct - All 5 versions
EM Allister, NM Borradaile, JY Edwards, MW Huff - Diabetes, 2005 - Am Diabetes Assoc Microsomal triglyceride transfer protein (MTP) is necessary for hepatocyte assembly and secretion
of apolipoprotein (apo)B100-containing lipoproteins. The citrus flavonoid naringenin, like
insulin, decreased MTP expression in HepG2 cells, resulting in inhibition of apoB100 ... Cited by 33 - Related articles - All 5 versions
NM Borradaile, LE de Dreu, PHR Barrett, CD Behrsin, … - Biochemistry, 2003 - pubs.acs.org Naringenin, the principal flavonoid in grapefruit, reduces plasma lipids in vivo and inhibits apoB
secretion, cholesterol esterification, and MTP activity in HepG2 human hepatoma cells. Although
naringenin inhibits ACAT, we recently demonstrated that CE availability in the microsomal ... Cited by 41 - Related articles - BL Direct - All 6 versions
AWSKHF Lin - Diabetes, 2003 - 万方数据资源系统 Microsomal triglyceride transfer protein (MTP) is rate limiting for the assembly and secretion of
apolipoprotein B-containing lipoproteins. Elevated hepatic MTP mRNA level, presumably as
a result of impaired insulin signaling, has been implicated inthe pathophysiology of ... Cited by 54 - Related articles - BL Direct - All 3 versions
- ►jlr.org NM Borradaile, LE de Dreu, PHR Barrett, MW Huff - The Journal of Lipid …, 2002 - ASBMB The grapefruit flavonoid, naringenin, is hypocholesterolemic in vivo, and inhibits basal apolipoprotein
B (apoB) secretion and the expression and activities of both ACAT and microsomal triglyceride
transfer protein (MTP) in human hepatoma cells (HepG2). In this report, we examined the ... Cited by 25 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] JD Sparks, TL Phung, M Bolognino, CE … - Biochemical …, 1996 - pubmedcentral.nih.gov Insulin inhibition of the secretion of apolipoprotein B (apo B) was studied in primary cultures
of rat hepatocytes by using brefeldin A (BFA), an inhibitor of protein transport from the endoplasmic
reticulum (ER) to the Golgi apparatus, and by using the phosphatidylinositol 3-kinase (PI ... Cited by 67 - Related articles - BL Direct - All 6 versions
MK Lee, SS Moon, SE Lee, SH Bok, TS Jeong, YB … - Bioorganic & medicinal …, 2003 - Elsevier A number of epidemiological studies have implied a role for flavonoids in reducing the risk of
coronary heart disease.[6, 7 and 8] Among naturally occurring flavonoids, hesperidin,
hesperetin, naringin, and naringenin have all been evaluated as potential agents for ... Cited by 24 - Related articles - All 6 versions
- ►jlr.org LJ Wilcox, NM Borradaile, LE de Dreu, MW Huff - The Journal of Lipid Research, 2001 - ASBMB The citrus flavonoids, naringenin and hesperetin, lower plasma cholesterol in vivo. However,
the underlying mechanisms are not fully understood. The ability of these flavonoids to modulate
apolipoprotein B (apoB) secretion and cellular cholesterol homeostasis was determined ... Cited by 74 - Related articles - BL Direct - All 5 versions
GS Choi, S Lee, TS Jeong, MK Lee, JS Lee, UJ … - Bioorganic & medicinal …, 2004 - Elsevier Numerous in vitro studies have revealed a close relationship between the chemical structure
and biologic activity of flavonoids, [11] and [12] whereby their basic structure can be modified
to increase or decrease their biologic activity. 13 As such, recent interest has focused on ... Cited by 6 - Related articles - All 5 versions
JS Choi, T Yokozawa, H Oura - Planta Med, 1991 - grande.nal.usda.gov Record Detail. Return to previous page, Save: Title: Improvement of hyperglycemia and
hyperlipemia in streptozotocin-diabetic rats by a methanolic extract of Prunus davidiana stems
and its main component, prunin. Author: Choi, JS : Yokozawa, T : Oura, H Citation: Planta-Med. ... Cited by 37 - Related articles - Cached - All 5 versions
