- ►diabetesjournals.org CC Wang, I Gurevich, B Draznin - Diabetes, 2003 - Am Diabetes Assoc Insulin maintains vascular smooth muscle cell (VSMC) quiescence yet can also promote VSMC
migration. The mechanisms by which insulin exerts these contrasting effects were examined
using -smooth muscle actin ( -SMA) as a marker of VSMC phenotype because -SMA is ... Cited by 69 - Related articles - BL Direct - All 4 versions
M Montagnani, I Golovchenko, I Kim, GY Koh, ML … - Journal of Biological …, 2002 - ASBMB The concept of “selective insulin resistance” has emerged as a unifying hypothesis in attempts
to reconcile the influence of insulin resistance with that of hyperinsulinemia in the pathogenesis
of macrovascular complications of diabetes. To explore this hypothesis in endothelial ... Cited by 167 - Related articles - BL Direct - All 4 versions
XP Xi, K Graf, S Goetze, WA Hsueh, RE Law - FEBS letters, 1997 - Elsevier Hyperinsulinemia is an independent risk factor for coronary artery disease [1]. Insulin induces
vascular smooth muscle cell (VSMC) proliferation, migration, and the production of extracellular
matrix which are critical processes for neointima formation in injured vessels [2]. ... Cited by 47 - Related articles - All 6 versions
R Madonna, A Pandolfi, M Massaro, A Consoli, RD … - Diabetologia, 2004 - Springer Aims/hypothesis. Although hyperinsulinaemia in Type 2 diabetes in states of insulin resistance
is a risk factor for atherosclerotic vascular disease, underlying mech- anisms are poorly
understood. We tested the hypothe- sis that insulin increases monocyte-endothelial inter- ... Cited by 40 - Related articles - BL Direct - All 4 versions
- ►nih.gov ZY Jiang, YW Lin, A Clemont, EP Feener, … - Journal of Clinical …, 1999 - Am Soc Clin Investig Both insulin resistance and hyperinsulinemia have been reported to be independent risk factors
for cardiovascular diseases. However, little is known regarding insulin signaling in the vascular
tissues in insulin-resistant states. In this report, insulin signaling on the ... Cited by 317 - Related articles - BL Direct - All 11 versions
- ►diabetesjournals.org CC Wang, ML Goalstone, B Draznin - Diabetes, 2004 - Am Diabetes Assoc Insulin resistance is concomitant with type 2 diabetes, obesity, hypertension, and other features
of the metabolic syndrome. Because insulin resistance is associated with cardiovascular
disease, both scientists and physicians have taken great interest in this disorder. Insulin ... Cited by 109 - Related articles - BL Direct - All 8 versions
- ►ahajournals.org I Golovchenko, ML Goalstone, P Watson, M … - Circulation …, 2000 - Am Heart Assoc Abstract—Pathogenesis of macrovascular complications of diabetes may involve an activation
of the transcription factor nuclear factor- B (NF- B) by hyperglycemia and advanced glycosylation
end products (AGEs). Activation of NF- B is believed to be dependent on activation of the ... Cited by 86 - Related articles - BL Direct - All 5 versions
- ►physiology.org A Jacob, JD Molkentin, A Smolenski, SM … - American Journal of …, 2002 - Am Physiological Soc In this study, we examined the role of insulin in the control of vascular smooth muscle cell
(VSMC) migration in the normal vasculature. Platelet-derived growth factor (PDGF) increased
VSMC migration, which was inhibited by pretreatment with insulin in a dose-dependent ... Cited by 39 - Related articles - BL Direct - All 5 versions
WA Hsueh, RE Law - The American journal of cardiology, 1999 - Elsevier Insulin has several direct vascular actions that contribute to either vascular protection or
injury, depending on the cell type. Vascular protective effects of insulin include stimulation of
endothelial cell production of the vasodilator nitric oxide (NO). This, in turn, inhibits ... Cited by 145 - Related articles - BL Direct - All 5 versions
