- ►diabetesjournals.org S Kiritoshi, T Nishikawa, K Sonoda, D Kukidome, T … - Diabetes, 2003 - Am Diabetes Assoc Hyperglycemia increases the production of reactive oxygen species (ROS) from the mitochondrial
electron transport chain in bovine endothelial cells. Because several studies have postulated
a role for prostaglandins (PGs) in the glomerular hyperfiltration seen in early diabetes, we ... Cited by 126 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org FR DeRubertis, PA Craven, MF Melhem, EM Salah - Diabetes, 2004 - Am Diabetes Assoc The effects of overexpression of Cu 2+ /Zn 2+ superoxide dismutase-1 (SOD-1) on indexes of
renal injury were compared in 5-month-old nontransgenic (NTg) db/db mice and db/db mice
hemizygous for the human SOD-1 transgene (SOD-Tg). Both diabetic groups exhibited ... Cited by 59 - Related articles - BL Direct - All 4 versions
PA Craven, MF Melhem, SL Phillips, FR DeRubertis - Diabetes, 2001 - Am Diabetes Assoc Ex vivo and in vitro observations implicate superoxide as a mediator of cell injury in
diabetes, but in vivo evidence is lacking. In the current studies, parameters of glomerular injury
were examined in hemizygous nondiabetic transgenic mice (SOD) and streptozotocin- ... Cited by 80 - Related articles - BL Direct - All 5 versions
- ►asnjournals.org D Koya, K Hayashi, M Kitada, A Kashiwagi, R … - Journal of the American …, 2003 - Am Soc Nephrol Diabetic nephropathy is a leading cause of end-stage renal failure, accounting for 35 to 40%
of all new cases that require dialysis therapy worldwide. Recent clinical studies clearly demonstrated
that hyperglycemia is an important causal factor in mediating the development and ... Cited by 81 - Related articles - BL Direct - All 6 versions
- ►nih.gov R Komers, JN Lindsley, TT Oyama, WE … - Journal of Clinical …, 2001 - Am Soc Clin Investig Prostaglandins (PGs) generated by the enzyme cyclooxygenase (COX) have been implicated
in the pathological renal hemodynamics and structural alterations in diabetes mellitus, but the
role of individual COX isoenzymes in diabetic nephropathy remains unknown. We ... Cited by 133 - Related articles - BL Direct - All 10 versions
- ►ahajournals.org F Cosentino, M Eto, P De Paolis, B van der Loo, M … - Circulation, 2003 - Am Heart Assoc Methods and Results— Human aortic endothelial cells were exposed to normal (5.5 mmol/L)
and high (22.2 mmol/L) glucose. Glucose selectively increased mRNA and protein expression
of COX-2. Its upregulation was associated with an increase of thromboxane A 2 and a ... Cited by 224 - Related articles - BL Direct - All 8 versions
- ►asnjournals.org JM Li, AM Shah - Journal of the American Society of Nephrology, 2003 - Am Soc Nephrol The NADPH oxidase was originally discovered in neutrophils, where it is a potent source of millimolar
quantities of superoxide (O 2 - ) during phagocytosis and plays a vital role in nonspecific host
defense (1). It comprises a membrane-associated cytochrome b 558 , composed of one ... Cited by 104 - Related articles - BL Direct - All 5 versions
- ►ahajournals.org J Quilley, YJ Chen - Hypertension, 2003 - Am Heart Assoc In the rat isolated perfused kidney, arachidonic acid elicits cyclooxygenase-dependent vasoconstriction
through activation of PGH 2 /TxA 2 receptors; responses are enhanced in kidneys from diabetic
rats. This study examined the roles of cyclooxygenase-1/cyclooxygenase-2 in the ... Cited by 24 - Related articles - BL Direct - All 7 versions
T Nishikawa, T Sasahara, S Kiritoshi, K Sonoda, T … - Diabetes Care, 2003 - Am Diabetes Assoc RESULTS—The urinary 8-OHdG:creatinine ratio (U8-OHdG) was 2.5-fold higher in patients with
increased HbA 1c than in those with normal HbA 1c (P < 0.05). In addition, U8-OHdG was
2.3-fold higher in patients with increased IMT (P < 0.005). A similar result was observed ... Cited by 56 - Related articles - BL Direct - All 5 versions
T Nishikawa, D Kukidome, K Sonoda, K Fujisawa, T … - Diabetes Research and …, 2007 - Elsevier Vascular complications are the leading cause of morbidity and mortality in patients with
diabetes. Four main molecular mechanisms have been implicated in glucose-mediated vascular
disease. There are: glucose-induced activation of protein kinase C (PKC) isoforms; ... Cited by 13 - Related articles - All 8 versions
