- ►hivinfosource.org [PDF] MJ Riedel, P Boora, D Steckley, G de Vries, … - Diabetes, 2003 - Am Diabetes Assoc The commonly occurring E23K and I337V Kir6.2 polymorphisms in the ATP-sensitive
potassium (K ATP ) channel are more frequent in Caucasian type 2 diabetic
populations. However, the underlying cellular mechanisms contributing to ... Cited by 51 - Related articles - BL Direct - All 25 versions
C Schwanstecher, B Neugebauer, M Schulz, … - Diabetes, 2002 - Am Diabetes Assoc E23K, a common polymorphism in the pore-forming subunit K IR 6.2 of pancreatic
β-cell ATP-sensitive K + (K ATP ) channels, is functionally relevant and thus
might play a major role in the pathophysiology of common type 2 diabetes. ... Cited by 32 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org C Schwanstecher, U Meyer, M … - Diabetes, 2002 - Am Diabetes Assoc E23K, a common single nucleotide polymorphism in K IR 6.2, the pore-forming
subunit of pancreatic β-cell ATP-sensitive K + channels, significantly enhanced
open probability of these channels, thus reducing their sensitivity toward ... Cited by 124 - Related articles - BL Direct - All 18 versions
- ►thelightlab.ca [PDF] MJ Riedel, DC Steckley, PE Light - Human genetics, 2005 - Springer Abstract The ATP-sensitive potassium (KATP) channel couples membrane
excitability to cellular metabolism and is a critical mediator in the process of
glucose- stimulated insulin secretion. Increasing numbers of KATP channel ... Cited by 33 - Related articles - All 5 versions
- ►nih.gov D Schulze, M Rapedius, T Krauter, T … - The Journal of Physiology, 2003 - Physiological Soc Phosphatidylinositol phosphates (PIPs, eg PIP 2 ) and long-chain acyl-CoA esters
(eg oleoyl-CoA) are potent activators of K atp channels that are thought to link
K atp channel activity to the cellular metabolism of PIPs and fatty acids. ... Cited by 44 - Related articles - BL Direct - All 7 versions
- ►shouxi.net MJ Riedel, PE Light - Diabetes, 2005 - Am Diabetes Assoc Metabolic regulation of pancreatic β-cell ATP-sensitive K + channel (K ATP
channel) function plays a key role in the process of glucose-stimulated insulin
secretion (GSIS). Modulation of K ATP channel activity by long-chain acyl ... Cited by 20 - Related articles - All 7 versions
O Tschritter, M Stumvoll, F Machicao, M … - Diabetes, 2002 - Am Diabetes Assoc Genetic factors play an important role in the pathogenesis of type 2 diabetes.
The relevance to type 2 diabetes of the common polymorphism Glu23Lys in the
potassium inward rectifier 6.2 (KIR6.2) gene is still controversial. The ... Cited by 44 - Related articles - BL Direct - All 5 versions
- ►physoc.org SA John, JN Weiss, LH Xie, B Ribalet - The Journal of Physiology, 2003 - Physiological Soc In the ATP-dependent K + (K ATP ) channel pore-forming protein Kir6.2, mutation
of three positively charged residues, R50, K185 and R201, impairs the ability of
ATP to close the channel. The mutations do not change the channel open ... Cited by 37 - Related articles - BL Direct - All 6 versions
EMD Nielsen, L Hansen, B Carstensen, SM … - Diabetes, 2003 - Am Diabetes Assoc The E23K polymorphism of the pancreatic β-cell ATP-sensitive K + (K ATP )
channel subunit Kir6.2 (KCNJ11) is associated with type 2 diabetes in whites,
and a recent in vitro study of the E23K variant suggests that the ... Cited by 146 - Related articles - BL Direct - All 5 versions
P Krippeit-Drews, M Bäcker, M Düfer, G … - Pflügers Archiv European Journal of Physiology, 2003 - Springer Abstract The aim of the present study was to test the hypothesis that a creatine
kinase/phosphocreatine system is involved in the regulation of K ATP channels in
pancreatic b-cells. The phosphocreatine concentration in isolated mouse ... Cited by 17 - Related articles - BL Direct - All 3 versions
