- ►diabetesjournals.org C Panagiotopoulos, H Qin, R Tan, CB Verchere - Diabetes, 2003 - Am Diabetes Assoc Type 1 diabetes is an autoimmune disease in which pancreatic β-cells are destroyed by cytotoxic
T-cells that recognize peptide epitopes presented by HLA class I molecules. The identification
of human β-cell epitopes may significantly improve the prospects for immunodiagnosis ... Cited by 49 - Related articles - BL Direct - All 4 versions
A Toma, S Haddouk, JP Briand, L … - Proceedings of the …, 2005 - National Acad Sciences Proinsulin is a key autoantigen in type 1 diabetes. Evidence in the mouse has underscored the
importance of the insulin B chain region in autoimmunity to pancreatic beta cells. In man, a majority
of proteasome cleavage sites are predicted by proteasome cleavage algorithms within ... Cited by 56 - Related articles - BL Direct - All 8 versions
C Panagiotopoulos, H Qin, R Tan, CB Verchere - DIABETES, 2003 - Am Diabetes Assoc Type 1 diabetes is an autoimmune disease in which pancreatic -cells are destroyed by cytotoxic
T-cells that recognize peptide epitopes presented by HLA class I molecules. The identification
of human -cell epitopes may significantly improve the prospects for immunodi- agnosis ... Related articles - All 2 versions
- ►rupress.org [PDF] P Panina-Bordignon, R Lang, PM Van Endert, … - Journal of Experimental …, 1995 - jem.rupress.org Summary Insulin-dependent diabetes meUitus (IDDM) is an autoimmune disease that results
in the destruction of the pancreatic islet 3 cells. Glutamic acid decarboxylase (GAD) has been
recently indicated as a key autoantigen in the induction of IDDM in nonobese diabetic ... Cited by 120 - Related articles - BL Direct - All 4 versions
Y Hassainya, F Garcia-Pons, R Kratzer, V Lindo, F … - Diabetes, 2005 - Am Diabetes Assoc Type 1 diabetes is thought to result from the destruction of β-cells by autoantigen-specific
T-cells. Observations in the NOD mouse model suggest that CD8 + cytotoxic T-cells play an essential
role in both the initial triggering of insulitis and its destructive phase. However, little is ... Cited by 43 - Related articles - All 6 versions
- ►diabetesjournals.org NE Standifer, Q Ouyang, C Panagiotopoulos, CB … - Diabetes, 2006 - Am Diabetes Assoc Cytotoxic T-lymphocytes (CTLs) are considered to be essential for β-cell destruction in type 1
diabetes. However, few islet-associated peptides have been demonstrated to activate autoreactive
CTLs from type 1 diabetic subjects. In an effort to identify novel epitopes, we used matrix- ... Cited by 28 - Related articles - BL Direct - All 5 versions
- ►jimmunol.org T Takaki, MP Marron, CE Mathews, ST … - The Journal of …, 2006 - Am Assoc Immnol In both humans and NOD mice, particular MHC genes are primary contributors to development
of the autoreactive CD4 + and CD8 + T cell responses against pancreatic cells that cause type
1 diabetes (T1D). Association studies have suggested, but not proved, that the ... Cited by 33 - Related articles - BL Direct - All 5 versions
K Kimura, T Kawamura, S Kadotani, H Inada, S … - Diabetes research and …, 2001 - Elsevier Cytotoxic T lymphocytes (CTL) against pancreatic β-cells probably play a major role in the etiology
of type 1 diabetes mellitus (DM). CTLs recognize a complex formed between MHC class I and
antigenic peptides fragments derived from intracellular processing of proteins. However, ... Cited by 14 - Related articles - All 6 versions
- ►diabetesjournals.org Q Ouyang, NE Standifer, H Qin, P Gottlieb, CB … - Diabetes, 2006 - Am Diabetes Assoc Type 1 diabetes results from the autoimmune destruction of insulin-producing pancreatic β-cells
by cytotoxic T-lymphocytes (CTLs). In humans, few β-cell epitopes have been reported, thereby
limiting the study of β-cell–specific CTLs in type 1 diabetes. To identify additional ... Cited by 37 - Related articles - BL Direct - All 4 versions
- ►pnas.org GGM Pinkse, OHM Tysma, CAM Bergen, … - Proceedings of the …, 2005 - National Acad Sciences Type 1 diabetes is a T cell-mediated autoimmune disease, and insulin is an important target
of the autoimmune response associated with β cell destruction. The mechanism of destruction
is still unknown. Here, we provide evidence for CD8 T cell autoreactivity associated with ... Cited by 88 - Related articles - BL Direct - All 10 versions
