TM Mizuno, KA Kelley, GM Pasinetti, JL Roberts, CV … - Diabetes, 2003 - Am Diabetes Assoc Hypothalamic proopiomelanocortin (POMC) gene expression is reduced in many forms of obesity
and diabetes, particularly in those attributable to deficiencies in leptin or its receptor. To assess
the functional significance of POMC in mediating metabolic phenotypes associated with ... Cited by 36 - Related articles - BL Direct - All 5 versions
- ►endojournals.org E Savontaus, TL Breen, A Kim, LM Yang, SC Chua Jr, … - Endocrinology, 2004 - Endocrine Soc The proopiomelanocortin-derived peptide, -MSH, inhibits feeding via melanocortin receptors
in the hypothalamus and genetic defects inactivating the melanocortin system have been shown
to lead to obesity in experimental animals and humans. To determine whether long-term ... Cited by 19 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org G Li, CV Mobbs, PJ Scarpace - Diabetes, 2003 - Am Diabetes Assoc Zucker (fa/fa) rats with defective leptin receptors are obese, hyperphagic, and
hyperinsulinemic. For testing whether chronic activation of the central melanocortin pathway
can bypass the defective leptin signaling and normalize altered energy homeostasis in ... Cited by 39 - Related articles - BL Direct - All 5 versions
G Li, Y Zhang, JT Wilsey, PJ Scarpace - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Age-related obesity is asso- ciated with impaired hypothalamic
pro-opiomelanocortin (Pomc) gene expression. We assessed whether overproduc- tion of POMC
in the hypothalamus ameliorates age-related obesity in rats. Methods: Recombinant ... Cited by 22 - Related articles - BL Direct - All 4 versions
- ►tno.co.jp [PDF] AC Heijboer, AM van den Hoek, H Pijl, PJ Voshol, LM … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: The present study was con- ducted to evaluate the effects of central
administration of melanotan II (MTII), a melanocortin-3/4 receptor agonist, on hepatic and
whole-body insulin sensitivity, independent of food intake and body weight. Methods: ... Cited by 13 - Related articles - BL Direct - All 4 versions
- ►endojournals.org DC Albarado, J McClaine, JM Stephens, RL Mynatt, J … - Endocrinology, 2004 - Endocrine Soc A reduction in metabolic rate and fatty acid (FA) oxidation, perhaps associated with low sympathetic
nervous activity, are thought to increase the risk of developing obesity and associated pathologies
such as diabetes and cardiovascular disease (5). To date, the most commonly found ... Cited by 27 - Related articles - BL Direct - All 7 versions
- ►endojournals.org GM Sutton, JL Trevaskis, MW Hulver, RP McMillan, NJ … - Endocrinology, 2006 - Endocrine Soc Loss of brain melanocortin receptors (Mc3rKO and Mc4rKO) causes increased adiposity and
exacerbates diet-induced obesity (DIO). Little is known about how Mc3r or Mc4r genotype,
diet, and obesity affect insulin sensitivity. Insulin resistance, assessed by insulin and ... Cited by 29 - Related articles - BL Direct - All 6 versions
- ►endojournals.org W Fan, DM Dinulescu, AA Butler, J Zhou, DL Marks, RD … - Endocrinology, 2000 - Endocrine Soc The central melanocortin system has been demonstrated to play a pivotal role in energy
homeostasis. Genetic disruption of this system causes obesity in both humans and mice. Previous
experiments have shown that centrally-administered melanocortin agonists inhibit food ... Cited by 114 - Related articles - BL Direct - All 3 versions
- ►endojournals.org SM Appleyard, M Hayward, JI Young, AA Butler, RD … - Endocrinology, 2003 - Endocrine Soc Proopiomelanocortin (POMC) neurons in the hypothalamus are direct targets of the adipostatic
hormone leptin and contribute to energy homeostasis by integrating peripheral and central
information. The melanocortin and ß-endorphin neuropeptides are processed from POMC ... Cited by 58 - Related articles - BL Direct - All 5 versions
- ►cjb.net T Adage, AJW Scheurink, SF de Boer, K de Vries, … - Journal of …, 2001 - neuro.cjb.net The CNS melanocortin (MC) system is implicated as a mediator of the central effects of
leptin, and reduced activity of the CNS MC system promotes obesity in both rodents and
humans. Because activation of CNS MC receptors has direct effects on autonomic outflow ... Cited by 61 - Related articles - BL Direct - All 6 versions
