- ►diabetesjournals.org CJ Padoa, JP Banga, AM Madec, M Ziegler, M … - Diabetes, 2003 - Am Diabetes Assoc Autoantibodies to the 65-kDa isoform of GAD (GAD65Abs) are associated with type 1 diabetes
development, but the conformational nature of the GAD65Ab epitopes complicates the evaluation of
disease risk. Six GAD65-specific ... Cited by 34 - Related articles - BL Direct - All 4 versions
- ►jimmunol.org JC Jaume, SL Parry, AM Madec, G … - The Journal of …, 2002 - Am Assoc Immnol Type 1 diabetes is a T cell-mediated disease in which B cells serve critical Ag-presenting
functions. In >95% of type 1 diabetic patients the B cell response to the glutamic acid
decarboxylase 65 (GAD65) ... Cited by 43 - Related articles - BL Direct - All 4 versions
- ►endojournals.org J Tremble, NG Morgenthaler, A Vlug, AC … - Journal of Clinical …, 1997 - Endocrine Soc Antibodies to glutamic acid decarboxylase-65 (GAD65) are present in a number of autoimmune
disorders, such as insulin-dependent (type 1) diabetes mellitus (IDDM), stiff man syndrome, and
polyendocrine autoimmune disease. ... Cited by 28 - Related articles - BL Direct - All 4 versions
M Schlosser, JP Banga, AM Madec, KA Binder, M … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Progression to type 1 diabetes is associated with intramolecular epitope
spreading to dis- ease-specific antibody epitopes located in the middle re- gion of glutamic acid
decarboxylase 65 (GAD65). Methods: ... Cited by 33 - Related articles - All 3 versions
- ►strgen.org [PDF] HL Schwartz, JM Chandonia, SF Kash, J Kanaani, … - Journal of molecular …, 1999 - Elsevier The smaller isoform of the GABA-synthesizing enzyme, glutamic acid decarboxylase 65 (GAD65), is
unusually susceptible to becoming a target of autoimmunity affecting its major sites of expression,
GABA-ergic neurons and pancreatic ... Cited by 65 - Related articles - BL Direct - All 6 versions
- ►endojournals.org CS Hampe, LP Hammerle, L Bekris, E Ortqvist, I … - Journal of Clinical …, 2000 - Endocrine Soc Autoantibodies against the smaller isoform of glutamic acid decarboxylase (GAD) are markers for Type
1 diabetes. GAD65 autoantibody (GAD65Ab)-positive individuals in the general population are,
however, mostly at low risk of ... Cited by 43 - Related articles - BL Direct - All 4 versions
JP Banga, JK Moore, N Duhindan, AM … - Clinical and …, 2004 - pubmedcentral.nih.gov We used a GAD65-specific human B–T cell line cognate system in vitro to investigate the modulation
of GAD65 presentation by autoantibody, assessed in a proliferation assay. Generally, if the T cell
determinant overlaps or resides ... Cited by 17 - Related articles - BL Direct - All 5 versions
- ►endojournals.org T Kobayashi, S Tanaka, M Okubo, K Nakanishi, … - Journal of Clinical …, 2003 - Endocrine Soc GAD65Ab in all SPIDDM samples reacted specifically with an N-terminal linear epitope located on the
membrane anchoring domain between amino acids 17–51 and C-terminal conformational epitope between
amino acids 443–585 of GAD65. The ... Cited by 33 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] CS Hampe, I Kockum, M Landin-Olsson, C Torn, E … - Diabetes Care, 2002 - Am Diabetes Assoc The provision of diabetes care has shifted from the specialist to the generalist in primary care
practice. Evidence suggests utilization of nonphy- sician providers in conjunction with phy-
sician-directed protocols improves ... Cited by 23 - Related articles - BL Direct - All 5 versions
AM Madec, F Rousset, S Ho, F Robert, C … - The Journal of …, 1996 - Am Assoc Immnol Page 1. Four IgG Anti-Islet Human Monoclonal Antibodies Isolated from a Type 1 Diabetes Patient Recognize
Distinct Epitopes of Glutamic Acid Decarboxylase 65 and Are Somatically Mutated Anne-Marie Madec,'*
Franqoise Rousset,t Stephen Ho,+ Franqois Robert,* Charles Thivolet,* ... Cited by 32 - Related articles - BL Direct - All 3 versions
