M Flodström-Tullberg, D Yadav, R Hägerkvist, … - Diabetes, 2003 - Am Diabetes Assoc Although lymphocyte infiltration and islet destruction are hallmarks of
diabetes, the mechanisms of β-cell destruction are not fully understood. One
issue that remains unresolved is whether cytokines play a direct role in ... Cited by 44 - Related articles - BL Direct - All 5 versions
- ►jimmunol.org MMW Chong, Y Chen, R Darwiche, NL Dudek, … - The Journal of Immunology, 2004 - Am Assoc Immnol In type 1 diabetes, cytokine action on cells potentially contributes to cell
destruction by direct cytotoxicity, inducing Fas expression, and up-regulating
class I MHC and chemokine expression to increase immune recognition. To ... Cited by 37 - Related articles - BL Direct - All 4 versions
M Solomon, M Flodström-Tullberg, N … - Transplantation, 2005 - journals.lww.com Skip Navigation Links Home > May 15, 2005 - Volume 79 - Issue 9 > Differences in
Suppressor of Cytokine Signaling-1 (SOCS-1) E... ... 1 Department of
Immunology, The Scripps Research Institute, La Jolla, CA. Cited by 10 - Related articles - All 4 versions
- ►diabetesjournals.org MMW Chong, HE Thomas, TWH Kay - Diabetes, 2001 - Am Diabetes Assoc Proinflammatory cytokines, including γ-interferon (IFN-γ), have been
implicated in the destruction of β-cells in autoimmune diabetes. IFN-γ
signaling is transient in some cell types, but there is indirect evidence ... Cited by 32 - Related articles - BL Direct - All 4 versions
MMW Chong, HE Thomas, TWH Kay - Journal of Biological Chemistry, 2002 - ASBMB Suppressor of cytokine signaling-1 (SOCS-1) is a negative regulator of the
Jak-STAT (signal transducer and activator of transcription cytokine) signaling
pathway but may also regulate other pathways. At least in vitro, SOCS-1 ... Cited by 55 - Related articles - BL Direct - All 5 versions
- ►pnas.org AE Karlsen, SG Rønn, K Lindberg, J … - Proceedings of the National Academy of Sciences, 2001 - National Acad Sciences Suppressor of cytokine signaling 3 (SOCS-3) is a negative feedback regulator of
IFN-γ signaling, shown up-regulated in mouse bone marrow cells by the
proinflammatory cytokines interleukin-1β (IL-1β), tumor necrosis ... Cited by 80 - Related articles - BL Direct - All 5 versions
AE Karlsen, PE Heding, H Frobøse, SG Rønn, M … - Diabetologia, 2004 - Springer Aims/hypothesis. The proinflammatory cytokine IL-1β induces apoptosis in
pancreatic beta cells via path- ways dependent on nuclear factor-κB (NF-κB),
mito- gen-activated protein kinase, and protein kinase C. We recently ... Cited by 25 - Related articles - All 3 versions
S Cottet, P Dupraz, F Hamburger, W Dolci, M … - Journal of Biological Chemistry, 2001 - ASBMB In the pathogenesis of type I diabetes mellitus, activated leukocytes infiltrate
pancreatic islets and induce cell dysfunction and destruction. Interferon (IFN)-
, tumor necrosis factor- and interleukin (IL)-1 play important, although ... Cited by 36 - Related articles - BL Direct - All 3 versions
- ►shouxi.net NL Dudek, HE Thomas, L Mariana, RM … - Diabetes, 2006 - Am Diabetes Assoc Cytotoxic T-cells are the major mediators of β-cell destruction in type 1
diabetes, but the molecular mechanisms are not definitively established. We have
examined the contribution of perforin and Fas ligand to β-cell destruction ... Cited by 19 - Related articles - BL Direct - All 6 versions
[CITATION] Interferon signaling in pancreatic-cells is persistent but can be terminated by overexpression …
