B Kutlu, AK Cardozo, MI Darville, M Kruhoffer … - DIABETES-NEW …, 2003 - Am Diabetes Assoc Locally released cytokines contribute to -cell dysfunc- tion and apoptosis in type 1 diabetes. In
vitro exposure of insulin-producing INS-1E cells to the cytokines inter- leukin (IL)-1 interferon
(IFN)- leads to a signifi- cant increase in apoptosis. To characterize the genetic networks ... Cited by 91 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org AK Cardozo, M Kruhøffer, R Leeman, T Ørntoft, DL … - Diabetes, 2001 - Am Diabetes Assoc Type 1 diabetes is an autoimmune disease resulting from the selective destruction of
insulin-producing β-cells. Cytokines may contribute to pancreatic β-cell death in type 1
diabetes. β-cell exposure to interleukin (IL)-1β induces functional impairment, whereas β- ... Cited by 145 - Related articles - BL Direct - All 4 versions
- ►daegu.ac.kr [PDF] J Rasschaert, D Liu, B Kutlu, AK Cardozo, M Kruhøffer, … - Diabetologia, 2003 - Springer Aims/hypothesis. Viral infections and local production of IFN-γ might contribute to beta-cell
dysfunction/ death in Type 1 Diabetes. Double stranded RNA (dsRNA) accumulates in the cytosol
of viral-infected cells, and exposure of purified rat beta cells to dsRNA (tested in the form ... Cited by 41 - Related articles - BL Direct - All 4 versions
AK Cardozo, H Heimberg, Y Heremans, R Leeman, … - Journal of Biological …, 2001 - ASBMB Type 1 diabetes mellitus results from an autoimmune destruction of pancreatic -cells.
Cytokines, such as interleukin-1 and interferon- , are putative mediators of immune-induced
-cell death and, under in vitro conditions, cause -cell apoptosis. We have recently shown ... Cited by 159 - Related articles - BL Direct - All 4 versions
DL Eizirik, B Kutlu, J Rasschaert, M … - ANNALS-NEW …, 2003 - interscience.wiley.com Abstract: The β cell fate following immune-mediated damage depends on an intricate pattern
of dozens of genes up- or downregulated in parallel and/or sequentially. We are utilizing microarray
analysis to clarify the pattern of gene expression in primary rat β cells exposed to the ... Cited by 32 - Related articles - BL Direct - All 5 versions
AK Cardozo, P Proost, C Gysemans, MC Chen, C … - Diabetologia, 2003 - Springer Aims/hypothesis. Cytokines and chemokines are im- portant mediators of immune responses
due to their ability to recruit and activate leukocytes. Using micro- array analysis we observed
that rat beta cells exposed to IL-1β and IFN-γ have increased mRNA levels of chemokines ... Cited by 86 - Related articles - BL Direct - All 5 versions
MI Darville, DL Eizirik - Diabetologia, 1998 - Springer Type I (insulin-dependent) diabetes mellitus results from a selective destruction of the pancreatic
insu- lin-producing beta cells. Cytokines, especially inter- leukin-1b (IL-1b), could play an important
role in im- mune-induced beta-cell damage [1, 2]. Several of the deleterious effects of ... Cited by 113 - Related articles - BL Direct - All 3 versions
- ►daegu.ac.kr [PDF] DL Eizirik, T Mandrup-Poulsen - Diabetologia, 2001 - Springer Apoptosis is likely to be the main form of beta-cell death in immune-mediated diabetes mellitus
in ro- dents and possibly in humans. Clarification of the regulation of beta-cell death could indicate
novel sites for therapeutic intervention in Type I (insulin- dependent) diabetes mellitus. ... Cited by 323 - Related articles - BL Direct - All 6 versions
AK Cardozo, F Ortis, J Storling, YM Feng, J Rasschaert, … - Diabetes, 2005 - Am Diabetes Assoc Cytokines and free radicals are mediators of β-cell death in type 1 diabetes. Under in vitro
conditions, interleukin-1β (IL-1β) + γ-interferon (IFN-γ) induce nitric oxide (NO) production and
apoptosis in rodent and human pancreatic β-cells. We have previously shown, by ... Cited by 102 - Related articles - All 8 versions
- ►diabetesjournals.org H Heimberg, Y Heremans, C Jobin, R Leemans, AK … - Diabetes, 2001 - Am Diabetes Assoc Cytokine-induced β-cell death is an important event in the pathogenesis of type 1 diabetes. The
transcription factor nuclear factor-κB (NF-κB) is activated by interleukin-1β (IL-1β), and its activity
promotes the expression of several β-cell genes, including pro- and anti-apoptotic genes. ... Cited by 129 - Related articles - BL Direct - All 4 versions
